Menin enhances c-Myc-mediated transcription to promote cancer progression

Menin enhances c-Myc-mediated transcription to promote cancer progression

Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent transformation independently of the MLL complex.

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Autores principales: Gongwei Wu, Mengqiu Yuan, Shengqi Shen, Xiaoyu Ma, Jingwen Fang, Lianbang Zhu, Linchong Sun, Zhaoji Liu, Xiaoping He, De Huang, Tingting Li, Chenchen Li, Jun Wu, Xin Hu, Zhaoyong Li, Libing Song, Kun Qu, Huafeng Zhang, Ping Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/eb251e3ef25c49b493a9316cb673b601
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spelling oai:doaj.org-article:eb251e3ef25c49b493a9316cb673b6012021-12-02T14:40:48ZMenin enhances c-Myc-mediated transcription to promote cancer progression10.1038/ncomms152782041-1723https://doaj.org/article/eb251e3ef25c49b493a9316cb673b6012017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15278https://doaj.org/toc/2041-1723Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent transformation independently of the MLL complex.Gongwei WuMengqiu YuanShengqi ShenXiaoyu MaJingwen FangLianbang ZhuLinchong SunZhaoji LiuXiaoping HeDe HuangTingting LiChenchen LiJun WuXin HuZhaoyong LiLibing SongKun QuHuafeng ZhangPing GaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gongwei Wu
Mengqiu Yuan
Shengqi Shen
Xiaoyu Ma
Jingwen Fang
Lianbang Zhu
Linchong Sun
Zhaoji Liu
Xiaoping He
De Huang
Tingting Li
Chenchen Li
Jun Wu
Xin Hu
Zhaoyong Li
Libing Song
Kun Qu
Huafeng Zhang
Ping Gao
Menin enhances c-Myc-mediated transcription to promote cancer progression
description Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent transformation independently of the MLL complex.
format article
author Gongwei Wu
Mengqiu Yuan
Shengqi Shen
Xiaoyu Ma
Jingwen Fang
Lianbang Zhu
Linchong Sun
Zhaoji Liu
Xiaoping He
De Huang
Tingting Li
Chenchen Li
Jun Wu
Xin Hu
Zhaoyong Li
Libing Song
Kun Qu
Huafeng Zhang
Ping Gao
author_facet Gongwei Wu
Mengqiu Yuan
Shengqi Shen
Xiaoyu Ma
Jingwen Fang
Lianbang Zhu
Linchong Sun
Zhaoji Liu
Xiaoping He
De Huang
Tingting Li
Chenchen Li
Jun Wu
Xin Hu
Zhaoyong Li
Libing Song
Kun Qu
Huafeng Zhang
Ping Gao
author_sort Gongwei Wu
title Menin enhances c-Myc-mediated transcription to promote cancer progression
title_short Menin enhances c-Myc-mediated transcription to promote cancer progression
title_full Menin enhances c-Myc-mediated transcription to promote cancer progression
title_fullStr Menin enhances c-Myc-mediated transcription to promote cancer progression
title_full_unstemmed Menin enhances c-Myc-mediated transcription to promote cancer progression
title_sort menin enhances c-myc-mediated transcription to promote cancer progression
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/eb251e3ef25c49b493a9316cb673b601
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