Antibacterial hemostatic dressings with nanoporous bioglass containing silver

Gangfeng Hu,1 Luwei Xiao,2 Peijian Tong,2 Dawei Bi,1 Hui Wang,1 Haitao Ma,1 Gang Zhu,1 Hui Liu21The First People&rsquo;s Hospital of Xiaoshan, Hangzhou, China; 2Zhejiang Traditional Chinese Medical University, Hangzhou, ChinaAbstract: Nanoporous bioglass containing silver (n-BGS) was fabrica...

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Autores principales:	Hu G, Xiao L, Tong P, Bi D, Wang H, Ma H, Zhu G, Liu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eb2fdebe767d4fb0bad78a3e5f9daf7d
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spelling	oai:doaj.org-article:eb2fdebe767d4fb0bad78a3e5f9daf7d2021-12-02T08:08:32ZAntibacterial hemostatic dressings with nanoporous bioglass containing silver1176-91141178-2013https://doaj.org/article/eb2fdebe767d4fb0bad78a3e5f9daf7d2012-05-01T00:00:00Zhttp://www.dovepress.com/antibacterial-hemostatic-dressings-with-nanoporous-bioglass-containing-a9983https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Gangfeng Hu,1 Luwei Xiao,2 Peijian Tong,2 Dawei Bi,1 Hui Wang,1 Haitao Ma,1 Gang Zhu,1 Hui Liu21The First People&rsquo;s Hospital of Xiaoshan, Hangzhou, China; 2Zhejiang Traditional Chinese Medical University, Hangzhou, ChinaAbstract: Nanoporous bioglass containing silver (n-BGS) was fabricated using the sol-gel method, with cetyltrimethyl ammonium bromide as template. The results showed that n-BGS with nanoporous structure had a surface area of 467 m2/g and a pore size of around 6 nm, and exhibited a significantly higher water absorption rate compared with BGS without nanopores. The n-BGS containing small amounts of silver (Ag) had a slight effect on its surface area. The n-BGS containing 0.02 wt% Ag, without cytotoxicity, had a good antibacterial effect on Escherichia coli, and its antibacterial rate reached 99% in 12 hours. The n-BGS&rsquo;s clotting ability significantly decreased prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating n-BGS with a higher surface area could significantly promote blood clotting (by decreasing clotting time) compared with BGS without nanopores. Effective hemostasis was achieved in skin injury models, and bleeding time was reduced. It is suggested that n-BGS could be a good dressing, with antibacterial and hemostatic properties, which might shorten wound bleeding time and control hemorrhage.Keywords: antibacterial, bioglass, cytotoxicity, dressing, hemostasis, nanopore, silverHu GXiao LTong PBi DWang HMa HZhu GLiu HDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2613-2620 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hu G Xiao L Tong P Bi D Wang H Ma H Zhu G Liu H Antibacterial hemostatic dressings with nanoporous bioglass containing silver
description	Gangfeng Hu,1 Luwei Xiao,2 Peijian Tong,2 Dawei Bi,1 Hui Wang,1 Haitao Ma,1 Gang Zhu,1 Hui Liu21The First People&rsquo;s Hospital of Xiaoshan, Hangzhou, China; 2Zhejiang Traditional Chinese Medical University, Hangzhou, ChinaAbstract: Nanoporous bioglass containing silver (n-BGS) was fabricated using the sol-gel method, with cetyltrimethyl ammonium bromide as template. The results showed that n-BGS with nanoporous structure had a surface area of 467 m2/g and a pore size of around 6 nm, and exhibited a significantly higher water absorption rate compared with BGS without nanopores. The n-BGS containing small amounts of silver (Ag) had a slight effect on its surface area. The n-BGS containing 0.02 wt% Ag, without cytotoxicity, had a good antibacterial effect on Escherichia coli, and its antibacterial rate reached 99% in 12 hours. The n-BGS&rsquo;s clotting ability significantly decreased prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating n-BGS with a higher surface area could significantly promote blood clotting (by decreasing clotting time) compared with BGS without nanopores. Effective hemostasis was achieved in skin injury models, and bleeding time was reduced. It is suggested that n-BGS could be a good dressing, with antibacterial and hemostatic properties, which might shorten wound bleeding time and control hemorrhage.Keywords: antibacterial, bioglass, cytotoxicity, dressing, hemostasis, nanopore, silver
format	article
author	Hu G Xiao L Tong P Bi D Wang H Ma H Zhu G Liu H
author_facet	Hu G Xiao L Tong P Bi D Wang H Ma H Zhu G Liu H
author_sort	Hu G
title	Antibacterial hemostatic dressings with nanoporous bioglass containing silver
title_short	Antibacterial hemostatic dressings with nanoporous bioglass containing silver
title_full	Antibacterial hemostatic dressings with nanoporous bioglass containing silver
title_fullStr	Antibacterial hemostatic dressings with nanoporous bioglass containing silver
title_full_unstemmed	Antibacterial hemostatic dressings with nanoporous bioglass containing silver
title_sort	antibacterial hemostatic dressings with nanoporous bioglass containing silver
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/eb2fdebe767d4fb0bad78a3e5f9daf7d
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Antibacterial hemostatic dressings with nanoporous bioglass containing silver

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