Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues.

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Autores principales:	Shahzada Khan, Irene Lew, Frank Wu, Linda Fritts, Krystal A. Fontaine, Sakshi Tomar, Martin Trapecar, Hesham M. Shehata, Melanie Ott, Christopher J. Miller, Shomyseh Sanjabi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb3899d102fc43d5bbcf48369a070e1a
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spelling	oai:doaj.org-article:eb3899d102fc43d5bbcf48369a070e1a2021-12-02T15:36:18ZLow expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract10.1038/s41467-019-12371-72041-1723https://doaj.org/article/eb3899d102fc43d5bbcf48369a070e1a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12371-7https://doaj.org/toc/2041-1723Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues.Shahzada KhanIrene LewFrank WuLinda FrittsKrystal A. FontaineSakshi TomarMartin TrapecarHesham M. ShehataMelanie OttChristopher J. MillerShomyseh SanjabiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shahzada Khan Irene Lew Frank Wu Linda Fritts Krystal A. Fontaine Sakshi Tomar Martin Trapecar Hesham M. Shehata Melanie Ott Christopher J. Miller Shomyseh Sanjabi Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
description	Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues.
format	article
author	Shahzada Khan Irene Lew Frank Wu Linda Fritts Krystal A. Fontaine Sakshi Tomar Martin Trapecar Hesham M. Shehata Melanie Ott Christopher J. Miller Shomyseh Sanjabi
author_facet	Shahzada Khan Irene Lew Frank Wu Linda Fritts Krystal A. Fontaine Sakshi Tomar Martin Trapecar Hesham M. Shehata Melanie Ott Christopher J. Miller Shomyseh Sanjabi
author_sort	Shahzada Khan
title	Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
title_short	Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
title_full	Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
title_fullStr	Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
title_full_unstemmed	Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
title_sort	low expression of rna sensors impacts zika virus infection in the lower female reproductive tract
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eb3899d102fc43d5bbcf48369a070e1a
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Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

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