IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling

CD4+ helper T cells producing IL-9 (Th9) have been implicated in anti-tumor immunity, with Th9 differentiation inducible in vitro via IL-4 and TGFβ treatment. Here the authors show that replacing TGFβ with IL-1β induces a distinct IL-9+ CD4+ population that have strong cytotoxic and anti-tumor activ...

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Autores principales:	Gang Xue, Guangxu Jin, Jing Fang, Yong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb394d7e86d64120afc9c415aba205e4
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spelling	oai:doaj.org-article:eb394d7e86d64120afc9c415aba205e42021-12-02T15:36:18ZIL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling10.1038/s41467-019-09401-92041-1723https://doaj.org/article/eb394d7e86d64120afc9c415aba205e42019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09401-9https://doaj.org/toc/2041-1723CD4+ helper T cells producing IL-9 (Th9) have been implicated in anti-tumor immunity, with Th9 differentiation inducible in vitro via IL-4 and TGFβ treatment. Here the authors show that replacing TGFβ with IL-1β induces a distinct IL-9+ CD4+ population that have strong cytotoxic and anti-tumor activity in preclinical mouse models.Gang XueGuangxu JinJing FangYong LuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Xue Guangxu Jin Jing Fang Yong Lu IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
description	CD4+ helper T cells producing IL-9 (Th9) have been implicated in anti-tumor immunity, with Th9 differentiation inducible in vitro via IL-4 and TGFβ treatment. Here the authors show that replacing TGFβ with IL-1β induces a distinct IL-9+ CD4+ population that have strong cytotoxic and anti-tumor activity in preclinical mouse models.
format	article
author	Gang Xue Guangxu Jin Jing Fang Yong Lu
author_facet	Gang Xue Guangxu Jin Jing Fang Yong Lu
author_sort	Gang Xue
title	IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
title_short	IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
title_full	IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
title_fullStr	IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
title_full_unstemmed	IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
title_sort	il-4 together with il-1β induces antitumor th9 cell differentiation in the absence of tgf-β signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eb394d7e86d64120afc9c415aba205e4
work_keys_str_mv	AT gangxue il4togetherwithil1binducesantitumorth9celldifferentiationintheabsenceoftgfbsignaling AT guangxujin il4togetherwithil1binducesantitumorth9celldifferentiationintheabsenceoftgfbsignaling AT jingfang il4togetherwithil1binducesantitumorth9celldifferentiationintheabsenceoftgfbsignaling AT yonglu il4togetherwithil1binducesantitumorth9celldifferentiationintheabsenceoftgfbsignaling
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IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling

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