IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling

IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling

CD4+ helper T cells producing IL-9 (Th9) have been implicated in anti-tumor immunity, with Th9 differentiation inducible in vitro via IL-4 and TGFβ treatment. Here the authors show that replacing TGFβ with IL-1β induces a distinct IL-9+ CD4+ population that have strong cytotoxic and anti-tumor activ...

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Autores principales: Gang Xue, Guangxu Jin, Jing Fang, Yong Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/eb394d7e86d64120afc9c415aba205e4
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