Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes

Oxidation of toluenes to benzaldehydes is usually accompanied by overoxidation products. Here, the authors report an iron-catalysed aerobic oxidation of methylarenes to benzaldehydes with high yields and selectivities, even in presence of boronic acid groups and in complex natural products and drugs...

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Auteurs principaux:	Penghui Hu, Mingxi Tan, Lu Cheng, Hongyuan Zhao, Rui Feng, Wei-Jin Gu, Wei Han
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/eb3a532783c94047ac7ad525216ec6e5
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spelling	oai:doaj.org-article:eb3a532783c94047ac7ad525216ec6e52021-12-02T16:58:05ZBio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes10.1038/s41467-019-10414-72041-1723https://doaj.org/article/eb3a532783c94047ac7ad525216ec6e52019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10414-7https://doaj.org/toc/2041-1723Oxidation of toluenes to benzaldehydes is usually accompanied by overoxidation products. Here, the authors report an iron-catalysed aerobic oxidation of methylarenes to benzaldehydes with high yields and selectivities, even in presence of boronic acid groups and in complex natural products and drugs.Penghui HuMingxi TanLu ChengHongyuan ZhaoRui FengWei-Jin GuWei HanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Penghui Hu Mingxi Tan Lu Cheng Hongyuan Zhao Rui Feng Wei-Jin Gu Wei Han Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes
description	Oxidation of toluenes to benzaldehydes is usually accompanied by overoxidation products. Here, the authors report an iron-catalysed aerobic oxidation of methylarenes to benzaldehydes with high yields and selectivities, even in presence of boronic acid groups and in complex natural products and drugs.
format	article
author	Penghui Hu Mingxi Tan Lu Cheng Hongyuan Zhao Rui Feng Wei-Jin Gu Wei Han
author_facet	Penghui Hu Mingxi Tan Lu Cheng Hongyuan Zhao Rui Feng Wei-Jin Gu Wei Han
author_sort	Penghui Hu
title	Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes
title_short	Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes
title_full	Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes
title_fullStr	Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes
title_full_unstemmed	Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes
title_sort	bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eb3a532783c94047ac7ad525216ec6e5
work_keys_str_mv	AT penghuihu bioinspiredironcatalyzedoxidationofalkylarenesenableslatestageoxidationofcomplexmethylarenestoarylaldehydes AT mingxitan bioinspiredironcatalyzedoxidationofalkylarenesenableslatestageoxidationofcomplexmethylarenestoarylaldehydes AT lucheng bioinspiredironcatalyzedoxidationofalkylarenesenableslatestageoxidationofcomplexmethylarenestoarylaldehydes AT hongyuanzhao bioinspiredironcatalyzedoxidationofalkylarenesenableslatestageoxidationofcomplexmethylarenestoarylaldehydes AT ruifeng bioinspiredironcatalyzedoxidationofalkylarenesenableslatestageoxidationofcomplexmethylarenestoarylaldehydes AT weijingu bioinspiredironcatalyzedoxidationofalkylarenesenableslatestageoxidationofcomplexmethylarenestoarylaldehydes AT weihan bioinspiredironcatalyzedoxidationofalkylarenesenableslatestageoxidationofcomplexmethylarenestoarylaldehydes
_version_	1718382421474279424

Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes

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