Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors

RBM7 and ZCCHC8 are two core subunits of the Nuclear Exosome Targeting complex, which regulates the degradation of selected non-coding RNAs in human cells. Here, the authors use structural and biochemical methods to show how ZCCHC8 recruits RBM7 in the complex, leaving the RNA binding site accessibl...

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Autores principales:	Sebastian Falk, Ksenia Finogenova, Mireille Melko, Christian Benda, Søren Lykke-Andersen, Torben Heick Jensen, Elena Conti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb3b13a071824d4d95e7463413ad6161
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spelling	oai:doaj.org-article:eb3b13a071824d4d95e7463413ad61612021-12-02T14:38:36ZStructure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors10.1038/ncomms135732041-1723https://doaj.org/article/eb3b13a071824d4d95e7463413ad61612016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13573https://doaj.org/toc/2041-1723RBM7 and ZCCHC8 are two core subunits of the Nuclear Exosome Targeting complex, which regulates the degradation of selected non-coding RNAs in human cells. Here, the authors use structural and biochemical methods to show how ZCCHC8 recruits RBM7 in the complex, leaving the RNA binding site accessible and revealing possible implications for splicing.Sebastian FalkKsenia FinogenovaMireille MelkoChristian BendaSøren Lykke-AndersenTorben Heick JensenElena ContiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian Falk Ksenia Finogenova Mireille Melko Christian Benda Søren Lykke-Andersen Torben Heick Jensen Elena Conti Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
description	RBM7 and ZCCHC8 are two core subunits of the Nuclear Exosome Targeting complex, which regulates the degradation of selected non-coding RNAs in human cells. Here, the authors use structural and biochemical methods to show how ZCCHC8 recruits RBM7 in the complex, leaving the RNA binding site accessible and revealing possible implications for splicing.
format	article
author	Sebastian Falk Ksenia Finogenova Mireille Melko Christian Benda Søren Lykke-Andersen Torben Heick Jensen Elena Conti
author_facet	Sebastian Falk Ksenia Finogenova Mireille Melko Christian Benda Søren Lykke-Andersen Torben Heick Jensen Elena Conti
author_sort	Sebastian Falk
title	Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
title_short	Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
title_full	Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
title_fullStr	Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
title_full_unstemmed	Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
title_sort	structure of the rbm7–zcchc8 core of the next complex reveals connections to splicing factors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/eb3b13a071824d4d95e7463413ad6161
work_keys_str_mv	AT sebastianfalk structureoftherbm7zcchc8coreofthenextcomplexrevealsconnectionstosplicingfactors AT kseniafinogenova structureoftherbm7zcchc8coreofthenextcomplexrevealsconnectionstosplicingfactors AT mireillemelko structureoftherbm7zcchc8coreofthenextcomplexrevealsconnectionstosplicingfactors AT christianbenda structureoftherbm7zcchc8coreofthenextcomplexrevealsconnectionstosplicingfactors AT sørenlykkeandersen structureoftherbm7zcchc8coreofthenextcomplexrevealsconnectionstosplicingfactors AT torbenheickjensen structureoftherbm7zcchc8coreofthenextcomplexrevealsconnectionstosplicingfactors AT elenaconti structureoftherbm7zcchc8coreofthenextcomplexrevealsconnectionstosplicingfactors
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Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors

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