Improving patient outcomes following glaucoma surgery: state of the art and future perspectives
Tine Van Bergen,1 Sarah Van de Velde,1 Evelien Vandewalle,3 Lieve Moons,2 Ingeborg Stalmans1,31Laboratory of Ophthalmology, KU Leuven, 2Unit Animal Physiology and Neurobiology, KU Leuven, 3Department of Ophthalmology, University Hospitals Leuven, Leuven, BelgiumAbstract: Of all the treatments curre...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/eb3bb11ec0214ab0b6636f69411c3718 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:eb3bb11ec0214ab0b6636f69411c3718 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:eb3bb11ec0214ab0b6636f69411c37182021-12-02T00:44:58ZImproving patient outcomes following glaucoma surgery: state of the art and future perspectives1177-5483https://doaj.org/article/eb3bb11ec0214ab0b6636f69411c37182014-05-01T00:00:00Zhttp://www.dovepress.com/improving-patient-outcomes-following-glaucoma-surgery-state-of-the-art-a16625https://doaj.org/toc/1177-5483 Tine Van Bergen,1 Sarah Van de Velde,1 Evelien Vandewalle,3 Lieve Moons,2 Ingeborg Stalmans1,31Laboratory of Ophthalmology, KU Leuven, 2Unit Animal Physiology and Neurobiology, KU Leuven, 3Department of Ophthalmology, University Hospitals Leuven, Leuven, BelgiumAbstract: Of all the treatments currently used to lower intraocular pressure in glaucoma patients, filtration surgery is known to be the most effective. However, in a significant percentage of cases, the constructed channel closes due to excessive scar formation, resulting in surgical failure. The process of postoperative wound healing is characterized by the coagulative and inflammatory phase, followed by the proliferative and repair phase, and finally the remodeling phase. Perioperative antimitotic agents, such as mitomycin C and 5-fluorouracil, are known to modulate the process of wound healing and to improve surgical outcome, but they carry a risk of vision-threatening complications. New alternative strategies to prevent filtration failure, such as inhibition of transforming growth factor-β, vascular endothelial growth factor, and placental growth factor, have shown promising results in the improvement of surgical success. However, it remains necessary to broaden the therapeutic approach by focusing on combined therapies and on extended drug delivery.Keywords: glaucoma filtration surgery, filtration failure, wound healing, wound modulating agentsVan Bergen TVan de Velde SVandewalle EMoons LStalmans IDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 857-867 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Ophthalmology RE1-994 |
| spellingShingle |
Ophthalmology RE1-994 Van Bergen T Van de Velde S Vandewalle E Moons L Stalmans I Improving patient outcomes following glaucoma surgery: state of the art and future perspectives |
| description |
Tine Van Bergen,1 Sarah Van de Velde,1 Evelien Vandewalle,3 Lieve Moons,2 Ingeborg Stalmans1,31Laboratory of Ophthalmology, KU Leuven, 2Unit Animal Physiology and Neurobiology, KU Leuven, 3Department of Ophthalmology, University Hospitals Leuven, Leuven, BelgiumAbstract: Of all the treatments currently used to lower intraocular pressure in glaucoma patients, filtration surgery is known to be the most effective. However, in a significant percentage of cases, the constructed channel closes due to excessive scar formation, resulting in surgical failure. The process of postoperative wound healing is characterized by the coagulative and inflammatory phase, followed by the proliferative and repair phase, and finally the remodeling phase. Perioperative antimitotic agents, such as mitomycin C and 5-fluorouracil, are known to modulate the process of wound healing and to improve surgical outcome, but they carry a risk of vision-threatening complications. New alternative strategies to prevent filtration failure, such as inhibition of transforming growth factor-β, vascular endothelial growth factor, and placental growth factor, have shown promising results in the improvement of surgical success. However, it remains necessary to broaden the therapeutic approach by focusing on combined therapies and on extended drug delivery.Keywords: glaucoma filtration surgery, filtration failure, wound healing, wound modulating agents |
| format |
article |
| author |
Van Bergen T Van de Velde S Vandewalle E Moons L Stalmans I |
| author_facet |
Van Bergen T Van de Velde S Vandewalle E Moons L Stalmans I |
| author_sort |
Van Bergen T |
| title |
Improving patient outcomes following glaucoma surgery: state of the art and future perspectives |
| title_short |
Improving patient outcomes following glaucoma surgery: state of the art and future perspectives |
| title_full |
Improving patient outcomes following glaucoma surgery: state of the art and future perspectives |
| title_fullStr |
Improving patient outcomes following glaucoma surgery: state of the art and future perspectives |
| title_full_unstemmed |
Improving patient outcomes following glaucoma surgery: state of the art and future perspectives |
| title_sort |
improving patient outcomes following glaucoma surgery: state of the art and future perspectives |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/eb3bb11ec0214ab0b6636f69411c3718 |
| work_keys_str_mv |
AT vanbergent improvingpatientoutcomesfollowingglaucomasurgerystateoftheartandfutureperspectives AT vandeveldes improvingpatientoutcomesfollowingglaucomasurgerystateoftheartandfutureperspectives AT vandewallee improvingpatientoutcomesfollowingglaucomasurgerystateoftheartandfutureperspectives AT moonsl improvingpatientoutcomesfollowingglaucomasurgerystateoftheartandfutureperspectives AT stalmansi improvingpatientoutcomesfollowingglaucomasurgerystateoftheartandfutureperspectives |
| _version_ |
1718403531433574400 |