Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease

Abstract Chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD) are both common diseases of the elderly people. COPD induced systemic inflammation and hypoxia may have an impact on the development of AMD. This study investigated the possible association between COPD...

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Autores principales:	Pei-Jane Bair, Ning-Yi Hsia, Cheng-Li Lin, Yu-Cih Yang, Te-Chun Shen, Chi‐Yuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb3db7e89b13495f9bc530d9216eab50
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spelling	oai:doaj.org-article:eb3db7e89b13495f9bc530d9216eab502021-12-02T17:57:15ZPopulation-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease10.1038/s41598-021-94657-92045-2322https://doaj.org/article/eb3db7e89b13495f9bc530d9216eab502021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94657-9https://doaj.org/toc/2045-2322Abstract Chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD) are both common diseases of the elderly people. COPD induced systemic inflammation and hypoxia may have an impact on the development of AMD. This study investigated the possible association between COPD and subsequent risk of AMD. A retrospective cohort study was conducted based on the data from the National Health Insurance Research Database in Taiwan. The COPD cohort comprised 24,625 adult patients newly diagnosed during 2000–2012, whereas age-, gender-, and the year of diagnosis-matched non-COPD cohort comprised 49,250 individuals. Incident AMD was monitored to the end of 2013. A Cox proportional hazards model was applied to evaluate the risk of AMD. The COPD cohort showed 1.25 times higher AMD incidence than the non-COPD cohort (4.80 versus 3.83 per 1000 person-years, adjusted hazard ratio (HR) = 1.20 [95% confident interval (CI) = 1.10–1.32]). Stratified analyses for age, gender, and presence of comorbidity resulted in significant adjusted HRs in most subgroups. Further analysis revealed that the COPD group had an increased risk of both the exudative and non-exudative types of AMD (adjusted HRs = 1.49 [95% CI = 1.13–1.96] and 1.15 [95% CI = 1.05–1.26], respectively). COPD patients have an increased risk for AMD development. Clinicians should provide adequate care for the ocular health to these patients.Pei-Jane BairNing-Yi HsiaCheng-Li LinYu-Cih YangTe-Chun ShenChi‐Yuan LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pei-Jane Bair Ning-Yi Hsia Cheng-Li Lin Yu-Cih Yang Te-Chun Shen Chi‐Yuan Li Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
description	Abstract Chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD) are both common diseases of the elderly people. COPD induced systemic inflammation and hypoxia may have an impact on the development of AMD. This study investigated the possible association between COPD and subsequent risk of AMD. A retrospective cohort study was conducted based on the data from the National Health Insurance Research Database in Taiwan. The COPD cohort comprised 24,625 adult patients newly diagnosed during 2000–2012, whereas age-, gender-, and the year of diagnosis-matched non-COPD cohort comprised 49,250 individuals. Incident AMD was monitored to the end of 2013. A Cox proportional hazards model was applied to evaluate the risk of AMD. The COPD cohort showed 1.25 times higher AMD incidence than the non-COPD cohort (4.80 versus 3.83 per 1000 person-years, adjusted hazard ratio (HR) = 1.20 [95% confident interval (CI) = 1.10–1.32]). Stratified analyses for age, gender, and presence of comorbidity resulted in significant adjusted HRs in most subgroups. Further analysis revealed that the COPD group had an increased risk of both the exudative and non-exudative types of AMD (adjusted HRs = 1.49 [95% CI = 1.13–1.96] and 1.15 [95% CI = 1.05–1.26], respectively). COPD patients have an increased risk for AMD development. Clinicians should provide adequate care for the ocular health to these patients.
format	article
author	Pei-Jane Bair Ning-Yi Hsia Cheng-Li Lin Yu-Cih Yang Te-Chun Shen Chi‐Yuan Li
author_facet	Pei-Jane Bair Ning-Yi Hsia Cheng-Li Lin Yu-Cih Yang Te-Chun Shen Chi‐Yuan Li
author_sort	Pei-Jane Bair
title	Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
title_short	Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
title_full	Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
title_fullStr	Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
title_full_unstemmed	Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
title_sort	population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb3db7e89b13495f9bc530d9216eab50
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Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease

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