Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells

Abstract This work aimed at formulating paclitaxel (PTX) loaded cell penetrating peptide (CPP) coated Mn doped ZnS nanoparticles (Mn:ZnS NPs) for improved anti-cancer efficacy in vitro and in vivo. The developed PTX loaded Mn:ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer...

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Autores principales:	N. Sanoj Rejinold, Yunho Han, Jisang Yoo, Hae Yong Seok, Ji Ho Park, Yeu-Chun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb4505cadb344e6a9bdadbcaa5388a1d
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spelling	oai:doaj.org-article:eb4505cadb344e6a9bdadbcaa5388a1d2021-12-02T15:08:25ZEvaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells10.1038/s41598-018-20255-x2045-2322https://doaj.org/article/eb4505cadb344e6a9bdadbcaa5388a1d2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20255-xhttps://doaj.org/toc/2045-2322Abstract This work aimed at formulating paclitaxel (PTX) loaded cell penetrating peptide (CPP) coated Mn doped ZnS nanoparticles (Mn:ZnS NPs) for improved anti-cancer efficacy in vitro and in vivo. The developed PTX loaded Mn:ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer effect compared to bare PTX, which has been validated by MTT assay followed by apoptosis assay and DNA fragmentation analysis. The in vivo bio-distribution and anti-cancer efficacy was studied on breast cancer xenograft model showing maximum tumor localization and enhanced therapeutic efficacy with R9 coated Mn:ZnS NPs (R9:Mn:ZnS NPs) and was confirmed by H/E staining. Thus, R9:Mn:ZnS NPs could be an ideal theranostic nano-carrier for PTX with enhanced the rapeutic efficacy toward cancer cells, where penetration and sustainability of therapeutics are essential.N. Sanoj RejinoldYunho HanJisang YooHae Yong SeokJi Ho ParkYeu-Chun KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q N. Sanoj Rejinold Yunho Han Jisang Yoo Hae Yong Seok Ji Ho Park Yeu-Chun Kim Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells
description	Abstract This work aimed at formulating paclitaxel (PTX) loaded cell penetrating peptide (CPP) coated Mn doped ZnS nanoparticles (Mn:ZnS NPs) for improved anti-cancer efficacy in vitro and in vivo. The developed PTX loaded Mn:ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer effect compared to bare PTX, which has been validated by MTT assay followed by apoptosis assay and DNA fragmentation analysis. The in vivo bio-distribution and anti-cancer efficacy was studied on breast cancer xenograft model showing maximum tumor localization and enhanced therapeutic efficacy with R9 coated Mn:ZnS NPs (R9:Mn:ZnS NPs) and was confirmed by H/E staining. Thus, R9:Mn:ZnS NPs could be an ideal theranostic nano-carrier for PTX with enhanced the rapeutic efficacy toward cancer cells, where penetration and sustainability of therapeutics are essential.
format	article
author	N. Sanoj Rejinold Yunho Han Jisang Yoo Hae Yong Seok Ji Ho Park Yeu-Chun Kim
author_facet	N. Sanoj Rejinold Yunho Han Jisang Yoo Hae Yong Seok Ji Ho Park Yeu-Chun Kim
author_sort	N. Sanoj Rejinold
title	Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells
title_short	Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells
title_full	Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells
title_fullStr	Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells
title_full_unstemmed	Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells
title_sort	evaluation of cell penetrating peptide coated mn:zns nanoparticles for paclitaxel delivery to cancer cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eb4505cadb344e6a9bdadbcaa5388a1d
work_keys_str_mv	AT nsanojrejinold evaluationofcellpenetratingpeptidecoatedmnznsnanoparticlesforpaclitaxeldeliverytocancercells AT yunhohan evaluationofcellpenetratingpeptidecoatedmnznsnanoparticlesforpaclitaxeldeliverytocancercells AT jisangyoo evaluationofcellpenetratingpeptidecoatedmnznsnanoparticlesforpaclitaxeldeliverytocancercells AT haeyongseok evaluationofcellpenetratingpeptidecoatedmnznsnanoparticlesforpaclitaxeldeliverytocancercells AT jihopark evaluationofcellpenetratingpeptidecoatedmnznsnanoparticlesforpaclitaxeldeliverytocancercells AT yeuchunkim evaluationofcellpenetratingpeptidecoatedmnznsnanoparticlesforpaclitaxeldeliverytocancercells
_version_	1718388159830556672

Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells

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