Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids

Background. Cissus quadrangularis Linn. (CQ) is a medicinal plant with good evidence for the treatment of hemorrhoids, listed in the Thai National List of Herbal Products in the oral dosage form. Acmella paniculata (Wall ex. DC.) R. K. Jansen. (AP) is a medicinal plant with a local anesthetic effect...

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Autores principales:	Kanokporn Niwatananun, Wirat Niwatananun, Sirivipa Piyamongkol, Darunee Hongwiset, Chidchanok Ruengorn, Kiatkriangkrai Koyratkoson, Panee Sirisa-ard, Sunee Chansakaow, Songwut Yotsawimonwat, Chalermpong Saenjum, Ampai Phrutivorapongkul, Suporn Charumanee
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/eb452c77c7614f858304e83fa8819c4b
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spelling	oai:doaj.org-article:eb452c77c7614f858304e83fa8819c4b2021-11-15T01:20:01ZClinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids1741-428810.1155/2021/5605323https://doaj.org/article/eb452c77c7614f858304e83fa8819c4b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5605323https://doaj.org/toc/1741-4288Background. Cissus quadrangularis Linn. (CQ) is a medicinal plant with good evidence for the treatment of hemorrhoids, listed in the Thai National List of Herbal Products in the oral dosage form. Acmella paniculata (Wall ex. DC.) R. K. Jansen. (AP) is a medicinal plant with a local anesthetic effect. Objective. To investigate the potential of rectal suppositories containing CQ and AP extracts to alleviate symptoms of hemorrhoids compared with the commercialized rectal suppository containing hydrocortisone and cinchocaine. Materials and Methods. Hemorrhoid outpatients (n = 105) with different severity grades (I, II, or III) from eight hospitals in northern Thailand were included in this study. Hemorrhoid severity was graded by proctoscopy associated with either anal pain or bleeding related to hemorrhoids or both. The patients were randomly allocated to two groups: CQ-AP group (n = 52) or the commercialized rectal suppository group (n = 53). One suppository was rectally administered twice daily in the morning and at bedtime for seven days. Evaluations were performed by physicians on days 1, 4, and 8 of the study. The primary endpoints were bleeding and prolapse size, while the secondary endpoint was anal pain. Results. Baseline demographics, lifestyle, constipation, number of prolapses, grade of hemorrhoid severity, and duration of experiencing hemorrhoids were comparable in both groups of patients. The effects of CQ-AP and the commercialized rectal suppository on bleeding, prolapse size, and anal pain were comparable. The patients in both groups were satisfied with both products at comparable levels and stated a preference for further use in the case of hemorrhoids recurrence. In terms of safety, the patients in the commercialized rectal suppository group experienced a higher incidence of adverse events, including anal pain and bleeding. Conclusion. Rectal suppositories containing a combined extract of CQ and AP show potential in alleviating hemorrhoidal symptoms with a good safety profile.Kanokporn NiwatananunWirat NiwatananunSirivipa PiyamongkolDarunee HongwisetChidchanok RuengornKiatkriangkrai KoyratkosonPanee Sirisa-ardSunee ChansakaowSongwut YotsawimonwatChalermpong SaenjumAmpai PhrutivorapongkulSuporn CharumaneeHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Kanokporn Niwatananun Wirat Niwatananun Sirivipa Piyamongkol Darunee Hongwiset Chidchanok Ruengorn Kiatkriangkrai Koyratkoson Panee Sirisa-ard Sunee Chansakaow Songwut Yotsawimonwat Chalermpong Saenjum Ampai Phrutivorapongkul Suporn Charumanee Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids
description	Background. Cissus quadrangularis Linn. (CQ) is a medicinal plant with good evidence for the treatment of hemorrhoids, listed in the Thai National List of Herbal Products in the oral dosage form. Acmella paniculata (Wall ex. DC.) R. K. Jansen. (AP) is a medicinal plant with a local anesthetic effect. Objective. To investigate the potential of rectal suppositories containing CQ and AP extracts to alleviate symptoms of hemorrhoids compared with the commercialized rectal suppository containing hydrocortisone and cinchocaine. Materials and Methods. Hemorrhoid outpatients (n = 105) with different severity grades (I, II, or III) from eight hospitals in northern Thailand were included in this study. Hemorrhoid severity was graded by proctoscopy associated with either anal pain or bleeding related to hemorrhoids or both. The patients were randomly allocated to two groups: CQ-AP group (n = 52) or the commercialized rectal suppository group (n = 53). One suppository was rectally administered twice daily in the morning and at bedtime for seven days. Evaluations were performed by physicians on days 1, 4, and 8 of the study. The primary endpoints were bleeding and prolapse size, while the secondary endpoint was anal pain. Results. Baseline demographics, lifestyle, constipation, number of prolapses, grade of hemorrhoid severity, and duration of experiencing hemorrhoids were comparable in both groups of patients. The effects of CQ-AP and the commercialized rectal suppository on bleeding, prolapse size, and anal pain were comparable. The patients in both groups were satisfied with both products at comparable levels and stated a preference for further use in the case of hemorrhoids recurrence. In terms of safety, the patients in the commercialized rectal suppository group experienced a higher incidence of adverse events, including anal pain and bleeding. Conclusion. Rectal suppositories containing a combined extract of CQ and AP show potential in alleviating hemorrhoidal symptoms with a good safety profile.
format	article
author	Kanokporn Niwatananun Wirat Niwatananun Sirivipa Piyamongkol Darunee Hongwiset Chidchanok Ruengorn Kiatkriangkrai Koyratkoson Panee Sirisa-ard Sunee Chansakaow Songwut Yotsawimonwat Chalermpong Saenjum Ampai Phrutivorapongkul Suporn Charumanee
author_facet	Kanokporn Niwatananun Wirat Niwatananun Sirivipa Piyamongkol Darunee Hongwiset Chidchanok Ruengorn Kiatkriangkrai Koyratkoson Panee Sirisa-ard Sunee Chansakaow Songwut Yotsawimonwat Chalermpong Saenjum Ampai Phrutivorapongkul Suporn Charumanee
author_sort	Kanokporn Niwatananun
title	Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids
title_short	Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids
title_full	Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids
title_fullStr	Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids
title_full_unstemmed	Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids
title_sort	clinical pilot study of rectal suppository containing combined extract of cissus quadrangularis linn. and acmella paniculata (wall ex. dc.) r. k. jansen in acute hemorrhoids
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/eb452c77c7614f858304e83fa8819c4b
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Clinical Pilot Study of Rectal Suppository Containing Combined Extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in Acute Hemorrhoids

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