Ferroptosis: The Silver Lining of Cancer Therapy

Regulatory cell death has been a major focus area of cancer therapy research to improve conventional clinical cancer treatment (e.g. chemotherapy and radiotherapy). Ferroptosis, a novel form of regulated cell death mediated by iron-dependent lipid peroxidation, has been receiving increasing attentio...

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Autores principales:	Zhengming Tang, Zhijie Huang, Yisheng Huang, Yuanxin Chen, Mingshu Huang, Hongyu Liu, Q. Adam Ye, Jianjiang Zhao, Bo Jia
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ferroptosis cancer therapy lipid peroxidation regulatory cell death reactive oxygen species Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/eb4571e7af744cdf90ad63dbf8264152
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id	oai:doaj.org-article:eb4571e7af744cdf90ad63dbf8264152
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spelling	oai:doaj.org-article:eb4571e7af744cdf90ad63dbf82641522021-12-01T13:34:58ZFerroptosis: The Silver Lining of Cancer Therapy2296-634X10.3389/fcell.2021.765859https://doaj.org/article/eb4571e7af744cdf90ad63dbf82641522021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.765859/fullhttps://doaj.org/toc/2296-634XRegulatory cell death has been a major focus area of cancer therapy research to improve conventional clinical cancer treatment (e.g. chemotherapy and radiotherapy). Ferroptosis, a novel form of regulated cell death mediated by iron-dependent lipid peroxidation, has been receiving increasing attention since its discovery in 2012. Owing to the highly iron-dependent physiological properties of cancer cells, targeting ferroptosis is a promising approach in cancer therapy. In this review, we summarised the characteristics of ferroptotic cells, associated mechanisms of ferroptosis occurrence and regulation and application of the ferroptotic pathway in cancer therapy, including the use of ferroptosis in combination with other therapeutic modalities. In addition, we presented the challenges of using ferroptosis in cancer therapy and future perspectives that may provide a basis for further research.Zhengming TangZhijie HuangYisheng HuangYuanxin ChenMingshu HuangHongyu LiuQ. Adam YeQ. Adam YeJianjiang ZhaoBo JiaFrontiers Media S.A.articleferroptosiscancer therapylipid peroxidationregulatory cell deathreactive oxygen speciesBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis cancer therapy lipid peroxidation regulatory cell death reactive oxygen species Biology (General) QH301-705.5
spellingShingle	ferroptosis cancer therapy lipid peroxidation regulatory cell death reactive oxygen species Biology (General) QH301-705.5 Zhengming Tang Zhijie Huang Yisheng Huang Yuanxin Chen Mingshu Huang Hongyu Liu Q. Adam Ye Q. Adam Ye Jianjiang Zhao Bo Jia Ferroptosis: The Silver Lining of Cancer Therapy
description	Regulatory cell death has been a major focus area of cancer therapy research to improve conventional clinical cancer treatment (e.g. chemotherapy and radiotherapy). Ferroptosis, a novel form of regulated cell death mediated by iron-dependent lipid peroxidation, has been receiving increasing attention since its discovery in 2012. Owing to the highly iron-dependent physiological properties of cancer cells, targeting ferroptosis is a promising approach in cancer therapy. In this review, we summarised the characteristics of ferroptotic cells, associated mechanisms of ferroptosis occurrence and regulation and application of the ferroptotic pathway in cancer therapy, including the use of ferroptosis in combination with other therapeutic modalities. In addition, we presented the challenges of using ferroptosis in cancer therapy and future perspectives that may provide a basis for further research.
format	article
author	Zhengming Tang Zhijie Huang Yisheng Huang Yuanxin Chen Mingshu Huang Hongyu Liu Q. Adam Ye Q. Adam Ye Jianjiang Zhao Bo Jia
author_facet	Zhengming Tang Zhijie Huang Yisheng Huang Yuanxin Chen Mingshu Huang Hongyu Liu Q. Adam Ye Q. Adam Ye Jianjiang Zhao Bo Jia
author_sort	Zhengming Tang
title	Ferroptosis: The Silver Lining of Cancer Therapy
title_short	Ferroptosis: The Silver Lining of Cancer Therapy
title_full	Ferroptosis: The Silver Lining of Cancer Therapy
title_fullStr	Ferroptosis: The Silver Lining of Cancer Therapy
title_full_unstemmed	Ferroptosis: The Silver Lining of Cancer Therapy
title_sort	ferroptosis: the silver lining of cancer therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/eb4571e7af744cdf90ad63dbf8264152
work_keys_str_mv	AT zhengmingtang ferroptosisthesilverliningofcancertherapy AT zhijiehuang ferroptosisthesilverliningofcancertherapy AT yishenghuang ferroptosisthesilverliningofcancertherapy AT yuanxinchen ferroptosisthesilverliningofcancertherapy AT mingshuhuang ferroptosisthesilverliningofcancertherapy AT hongyuliu ferroptosisthesilverliningofcancertherapy AT qadamye ferroptosisthesilverliningofcancertherapy AT qadamye ferroptosisthesilverliningofcancertherapy AT jianjiangzhao ferroptosisthesilverliningofcancertherapy AT bojia ferroptosisthesilverliningofcancertherapy
_version_	1718405149038215168

Ferroptosis: The Silver Lining of Cancer Therapy

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