GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b

Abstract. For many years, the viral hepatitis C is considered as one of the most actual infectious pathologies of human. During the last decade the number of registered cases of chronic viral hepatitis C in Russia increased two times and reached 40.9‰. According to the current virological classifica...

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Autor principal:	O. V. Kalinina
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	hcv natural recombinant rf1_2k/1b genome organization geographical distribution Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/eb47527f724d42bc9351feed99e66d24
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spelling	oai:doaj.org-article:eb47527f724d42bc9351feed99e66d242021-11-22T07:09:46ZGENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b2220-76192313-739810.15789/2220-7619-2012-4-677-686https://doaj.org/article/eb47527f724d42bc9351feed99e66d242014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/104https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. For many years, the viral hepatitis C is considered as one of the most actual infectious pathologies of human. During the last decade the number of registered cases of chronic viral hepatitis C in Russia increased two times and reached 40.9‰. According to the current virological classification, hepatitis C virus (HCV) is differentiated into 6 genotypes and more than 200 subtypes. At the same time, increasing number of publications report about novel genetic variants of HCV. A high mutation rate is considered to be a major factor behind HCV genetic diversity. Recombination as another mechanism for creating genetic variation was not recognized as important factor for generating the HCV diversity. For a long time it was believed that the natural recombinants of hepatitis C virus were not viable. The first inter-genotype HCV recombinant RF1_2k/1b was identified in 2002 in Saint-Petersburg. The structural genes of the recombinant strain were similar to those of the HCV subtype 2k, while its nonstructural genes (except for the part of the NS2 gene) belonged to the HCV subtype 1b. Since that time, many studies were initiated to indentify natural HCV recombinants. This review presents current data regarding the genomic organization of HCV and its natural inter-genotype recombinant RF1_2k/1b as well as information about circulation of this recombinant in the world.O. V. KalininaSankt-Peterburg : NIIÈM imeni Pasteraarticlehcv natural recombinant rf1_2k/1bgenome organizationgeographical distributionInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 4, Pp 677-686 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hcv natural recombinant rf1_2k/1b genome organization geographical distribution Infectious and parasitic diseases RC109-216
spellingShingle	hcv natural recombinant rf1_2k/1b genome organization geographical distribution Infectious and parasitic diseases RC109-216 O. V. Kalinina GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b
description	Abstract. For many years, the viral hepatitis C is considered as one of the most actual infectious pathologies of human. During the last decade the number of registered cases of chronic viral hepatitis C in Russia increased two times and reached 40.9‰. According to the current virological classification, hepatitis C virus (HCV) is differentiated into 6 genotypes and more than 200 subtypes. At the same time, increasing number of publications report about novel genetic variants of HCV. A high mutation rate is considered to be a major factor behind HCV genetic diversity. Recombination as another mechanism for creating genetic variation was not recognized as important factor for generating the HCV diversity. For a long time it was believed that the natural recombinants of hepatitis C virus were not viable. The first inter-genotype HCV recombinant RF1_2k/1b was identified in 2002 in Saint-Petersburg. The structural genes of the recombinant strain were similar to those of the HCV subtype 2k, while its nonstructural genes (except for the part of the NS2 gene) belonged to the HCV subtype 1b. Since that time, many studies were initiated to indentify natural HCV recombinants. This review presents current data regarding the genomic organization of HCV and its natural inter-genotype recombinant RF1_2k/1b as well as information about circulation of this recombinant in the world.
format	article
author	O. V. Kalinina
author_facet	O. V. Kalinina
author_sort	O. V. Kalinina
title	GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b
title_short	GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b
title_full	GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b
title_fullStr	GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b
title_full_unstemmed	GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b
title_sort	genome organization and geographical distribution of the natural intergenotypic recombinant of hepatitis c virus rf1_2k/1b
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/eb47527f724d42bc9351feed99e66d24
work_keys_str_mv	AT ovkalinina genomeorganizationandgeographicaldistributionofthenaturalintergenotypicrecombinantofhepatitiscvirusrf12k1b
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GENOME ORGANIZATION AND GEOGRAPHICAL DISTRIBUTION OF THE NATURAL INTERGENOTYPIC RECOMBINANT OF HEPATITIS C VIRUS RF1_2k/1b

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