Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial

Abstract This study aimed to examine the effect of repeated anodal cerebellar transcranial direct current stimulation (ctDCS) on learning a split-belt treadmill task. Thirty healthy individuals randomly received three consecutive sessions of active or sham anodal ctDCS during split-belt treadmill tr...

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Autores principales:	Nitika Kumari, Denise Taylor, Usman Rashid, Alain C. Vandal, Paul F. Smith, Nada Signal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb47985f094440c2a8716877eeb3f7b4
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spelling	oai:doaj.org-article:eb47985f094440c2a8716877eeb3f7b42021-12-02T15:33:10ZCerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial10.1038/s41598-020-68825-22045-2322https://doaj.org/article/eb47985f094440c2a8716877eeb3f7b42020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68825-2https://doaj.org/toc/2045-2322Abstract This study aimed to examine the effect of repeated anodal cerebellar transcranial direct current stimulation (ctDCS) on learning a split-belt treadmill task. Thirty healthy individuals randomly received three consecutive sessions of active or sham anodal ctDCS during split-belt treadmill training. Motor performance and strides to steady-state performance were evaluated before (baseline), during (adaptation), and after (de-adaptation) the intervention. The outcomes were measured one week later to assess absolute learning and during the intervention to evaluate cumulative, consecutive, and session-specific effects. Data were analysed using linear mixed-effects regression models. During adaptation, there was no significant difference in absolute learning between the groups (p > 0.05). During de-adaptation, a significant difference in absolute learning between the groups (p = 0.03) indicated slower de-adaptation with anodal ctDCS. Pre-planned secondary analysis revealed that anodal ctDCS significantly reduced the cumulative (p = 0.01) and consecutive-session effect (p = 0.01) on immediate adaptation. There were significant cumulative (p = 0.02) and session-specific effects (p = 0.003) on immediate de-adaptation. Repeated anodal ctDCS does not enhance motor learning measured during adaptation to a split-belt treadmill task. However, it influences the maintenance of learnt walking patterns, suggesting that it may be beneficial in maintaining therapeutic effects.Nitika KumariDenise TaylorUsman RashidAlain C. VandalPaul F. SmithNada SignalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nitika Kumari Denise Taylor Usman Rashid Alain C. Vandal Paul F. Smith Nada Signal Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial
description	Abstract This study aimed to examine the effect of repeated anodal cerebellar transcranial direct current stimulation (ctDCS) on learning a split-belt treadmill task. Thirty healthy individuals randomly received three consecutive sessions of active or sham anodal ctDCS during split-belt treadmill training. Motor performance and strides to steady-state performance were evaluated before (baseline), during (adaptation), and after (de-adaptation) the intervention. The outcomes were measured one week later to assess absolute learning and during the intervention to evaluate cumulative, consecutive, and session-specific effects. Data were analysed using linear mixed-effects regression models. During adaptation, there was no significant difference in absolute learning between the groups (p > 0.05). During de-adaptation, a significant difference in absolute learning between the groups (p = 0.03) indicated slower de-adaptation with anodal ctDCS. Pre-planned secondary analysis revealed that anodal ctDCS significantly reduced the cumulative (p = 0.01) and consecutive-session effect (p = 0.01) on immediate adaptation. There were significant cumulative (p = 0.02) and session-specific effects (p = 0.003) on immediate de-adaptation. Repeated anodal ctDCS does not enhance motor learning measured during adaptation to a split-belt treadmill task. However, it influences the maintenance of learnt walking patterns, suggesting that it may be beneficial in maintaining therapeutic effects.
format	article
author	Nitika Kumari Denise Taylor Usman Rashid Alain C. Vandal Paul F. Smith Nada Signal
author_facet	Nitika Kumari Denise Taylor Usman Rashid Alain C. Vandal Paul F. Smith Nada Signal
author_sort	Nitika Kumari
title	Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial
title_short	Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial
title_full	Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial
title_fullStr	Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial
title_full_unstemmed	Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial
title_sort	cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/eb47985f094440c2a8716877eeb3f7b4
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Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial

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