Structural basis of substrate recognition and translocation by human ABCA4

Here, cryo-EM structures of human retinal ABCA4 transporter, either in apo state, in complex with ATP or with the physiological lipid substrate N-retinylidene-phosphatidylethanolamine (NRPE), reveal lateral opening, substrate recognition and suggest ‘lateral access and extrusion’ mechanism for ABCA-...

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Autores principales:	Tian Xie, Zike Zhang, Qi Fang, Bowen Du, Xin Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb492f4b734c4a06849ad264dacdecf4
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spelling	oai:doaj.org-article:eb492f4b734c4a06849ad264dacdecf42021-12-02T17:14:22ZStructural basis of substrate recognition and translocation by human ABCA410.1038/s41467-021-24194-62041-1723https://doaj.org/article/eb492f4b734c4a06849ad264dacdecf42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24194-6https://doaj.org/toc/2041-1723Here, cryo-EM structures of human retinal ABCA4 transporter, either in apo state, in complex with ATP or with the physiological lipid substrate N-retinylidene-phosphatidylethanolamine (NRPE), reveal lateral opening, substrate recognition and suggest ‘lateral access and extrusion’ mechanism for ABCA-mediated lipid transport.Tian XieZike ZhangQi FangBowen DuXin GongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tian Xie Zike Zhang Qi Fang Bowen Du Xin Gong Structural basis of substrate recognition and translocation by human ABCA4
description	Here, cryo-EM structures of human retinal ABCA4 transporter, either in apo state, in complex with ATP or with the physiological lipid substrate N-retinylidene-phosphatidylethanolamine (NRPE), reveal lateral opening, substrate recognition and suggest ‘lateral access and extrusion’ mechanism for ABCA-mediated lipid transport.
format	article
author	Tian Xie Zike Zhang Qi Fang Bowen Du Xin Gong
author_facet	Tian Xie Zike Zhang Qi Fang Bowen Du Xin Gong
author_sort	Tian Xie
title	Structural basis of substrate recognition and translocation by human ABCA4
title_short	Structural basis of substrate recognition and translocation by human ABCA4
title_full	Structural basis of substrate recognition and translocation by human ABCA4
title_fullStr	Structural basis of substrate recognition and translocation by human ABCA4
title_full_unstemmed	Structural basis of substrate recognition and translocation by human ABCA4
title_sort	structural basis of substrate recognition and translocation by human abca4
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb492f4b734c4a06849ad264dacdecf4
work_keys_str_mv	AT tianxie structuralbasisofsubstraterecognitionandtranslocationbyhumanabca4 AT zikezhang structuralbasisofsubstraterecognitionandtranslocationbyhumanabca4 AT qifang structuralbasisofsubstraterecognitionandtranslocationbyhumanabca4 AT bowendu structuralbasisofsubstraterecognitionandtranslocationbyhumanabca4 AT xingong structuralbasisofsubstraterecognitionandtranslocationbyhumanabca4
_version_	1718381354616356864

Structural basis of substrate recognition and translocation by human ABCA4

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