Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report

Cryptococcosis is frequently found in immunosuppressed patients. It is also a significant opportunistic infection in non-immunocompromised individuals. In this study, we present a rare case of membranous nephropathy (MN) with pulmonary cryptococcosis. A 33-year-old man with MN was referred to our ho...

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Autores principales:	Zhang Peipei, Wang Chundan, Zhang Jiudan, Zhong Wenjing, Xia Hong
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	cryptococcus neoformans membranous nephropathy pulmonary cryptococcosis anti-fungal drugs Medicine R
Acceso en línea:	https://doaj.org/article/eb4f22a52fa44eeea19d9afa2e805540
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spelling	oai:doaj.org-article:eb4f22a52fa44eeea19d9afa2e8055402021-12-05T14:10:54ZMembranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report2391-546310.1515/med-2021-0234https://doaj.org/article/eb4f22a52fa44eeea19d9afa2e8055402021-02-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0234https://doaj.org/toc/2391-5463Cryptococcosis is frequently found in immunosuppressed patients. It is also a significant opportunistic infection in non-immunocompromised individuals. In this study, we present a rare case of membranous nephropathy (MN) with pulmonary cryptococcosis. A 33-year-old man with MN was referred to our hospital because of dyspnea and weakness for 1 week. Before the above symptoms occurred, the dose of Cyclosporin A was increased again for relapse of MN. Multiple massive or patchy high-density shadows were present on computed tomography of the lung. Initially the patient underwent empirical anti-bacterial therapy, which turned out to be ineffective. As the results of serum cryptococcal latex agglutination tests were positive, the administration of anti-fungal drugs was prescribed. The results of fungal culture and pathologic examination of the lung tissue revealed the findings consistent with Cryptococcus neoformans. The patient was successfully treated with voriconazole followed by fluconazole with satisfactory result. Therefore, in patients with chronic kidney disease, lung lesions with poor bactericidal effects of cephalosporins need further examination to make sure whether there is pulmonary cryptococcosis. Early diagnosis and treatment might contribute to good results. It is a problem worthy of consideration that whether immunosuppressive agents need to be discontinued or not during antifungal therapy.Zhang PeipeiWang ChundanZhang JiudanZhong WenjingXia HongDe Gruyterarticlecryptococcus neoformansmembranous nephropathypulmonary cryptococcosisanti-fungal drugsMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 311-315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cryptococcus neoformans membranous nephropathy pulmonary cryptococcosis anti-fungal drugs Medicine R
spellingShingle	cryptococcus neoformans membranous nephropathy pulmonary cryptococcosis anti-fungal drugs Medicine R Zhang Peipei Wang Chundan Zhang Jiudan Zhong Wenjing Xia Hong Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report
description	Cryptococcosis is frequently found in immunosuppressed patients. It is also a significant opportunistic infection in non-immunocompromised individuals. In this study, we present a rare case of membranous nephropathy (MN) with pulmonary cryptococcosis. A 33-year-old man with MN was referred to our hospital because of dyspnea and weakness for 1 week. Before the above symptoms occurred, the dose of Cyclosporin A was increased again for relapse of MN. Multiple massive or patchy high-density shadows were present on computed tomography of the lung. Initially the patient underwent empirical anti-bacterial therapy, which turned out to be ineffective. As the results of serum cryptococcal latex agglutination tests were positive, the administration of anti-fungal drugs was prescribed. The results of fungal culture and pathologic examination of the lung tissue revealed the findings consistent with Cryptococcus neoformans. The patient was successfully treated with voriconazole followed by fluconazole with satisfactory result. Therefore, in patients with chronic kidney disease, lung lesions with poor bactericidal effects of cephalosporins need further examination to make sure whether there is pulmonary cryptococcosis. Early diagnosis and treatment might contribute to good results. It is a problem worthy of consideration that whether immunosuppressive agents need to be discontinued or not during antifungal therapy.
format	article
author	Zhang Peipei Wang Chundan Zhang Jiudan Zhong Wenjing Xia Hong
author_facet	Zhang Peipei Wang Chundan Zhang Jiudan Zhong Wenjing Xia Hong
author_sort	Zhang Peipei
title	Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report
title_short	Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report
title_full	Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report
title_fullStr	Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report
title_full_unstemmed	Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report
title_sort	membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: a case report
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/eb4f22a52fa44eeea19d9afa2e805540
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Membranous nephropathy with pulmonary cryptococcosis with improved 1-year follow-up results: A case report

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