CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS

Аbstract. The objective of present study was to determine the immunological features of immune system aging in mucosa-associated lymphoid tissue (MALT) in the patients at different ages (mature, aging and old) observed at a dental unit. A study of cellular spectrum and humoral factors in salivary gl...

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Autores principales:	E. D. Altman, A. V. Zurochka, S. N. Teplova, E. V. Davydova, D. Sh. Altman
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	aging oral mucosa immunocytes immunoglobulins complement mucine Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/eb5048d8f7524cad929cd4753282fec5
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spelling	oai:doaj.org-article:eb5048d8f7524cad929cd4753282fec52021-11-18T08:03:41ZCHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS1563-06252313-741X10.15789/1563-0625-2011-2-3-167-174https://doaj.org/article/eb5048d8f7524cad929cd4753282fec52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/440https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. The objective of present study was to determine the immunological features of immune system aging in mucosa-associated lymphoid tissue (MALT) in the patients at different ages (mature, aging and old) observed at a dental unit. A study of cellular spectrum and humoral factors in salivary gland secretions has been performed in a group of 106 persons (35 to 90 years old). A number of age-dependent features of the immune profile were revealed for the mucous-salivary area, thus characterizing involution events within MALT structures. Among specific markers determining intensity of MALT-associated aging, a decreased percentage of viable immune cells (below 40%), along with the prevalence of the neutrophilic granulocytes in the salivary secretions (over 98%) (with increased expression of β2-integrins); decreased counts of mononuclear cells, i.e., mononuclear cells with low expression of CD11β adhesion molecules, B-lymhocytes, and Th-lymphocytes have been revealed. Alterations in serum factors included a general decrease in complement system activity (СН50) and anaphylotoxines (С3а,С5а); elevated protein, mucine, and IgМ levels. The revealed specific features of cellular and humoral immunity within MALT-associated muco-salivary zone may be considered as a normal response connected with natural aging processes. (Med. Immunol., 2011, vol. 13, N 2-3, pp 167-174)E. D. AltmanA. V. ZurochkaS. N. TeplovaE. V. DavydovaD. Sh. AltmanSPb RAACIarticleagingoral mucosaimmunocytesimmunoglobulinscomplementmucineImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 167-174 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	aging oral mucosa immunocytes immunoglobulins complement mucine Immunologic diseases. Allergy RC581-607
spellingShingle	aging oral mucosa immunocytes immunoglobulins complement mucine Immunologic diseases. Allergy RC581-607 E. D. Altman A. V. Zurochka S. N. Teplova E. V. Davydova D. Sh. Altman CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS
description	Аbstract. The objective of present study was to determine the immunological features of immune system aging in mucosa-associated lymphoid tissue (MALT) in the patients at different ages (mature, aging and old) observed at a dental unit. A study of cellular spectrum and humoral factors in salivary gland secretions has been performed in a group of 106 persons (35 to 90 years old). A number of age-dependent features of the immune profile were revealed for the mucous-salivary area, thus characterizing involution events within MALT structures. Among specific markers determining intensity of MALT-associated aging, a decreased percentage of viable immune cells (below 40%), along with the prevalence of the neutrophilic granulocytes in the salivary secretions (over 98%) (with increased expression of β2-integrins); decreased counts of mononuclear cells, i.e., mononuclear cells with low expression of CD11β adhesion molecules, B-lymhocytes, and Th-lymphocytes have been revealed. Alterations in serum factors included a general decrease in complement system activity (СН50) and anaphylotoxines (С3а,С5а); elevated protein, mucine, and IgМ levels. The revealed specific features of cellular and humoral immunity within MALT-associated muco-salivary zone may be considered as a normal response connected with natural aging processes. (Med. Immunol., 2011, vol. 13, N 2-3, pp 167-174)
format	article
author	E. D. Altman A. V. Zurochka S. N. Teplova E. V. Davydova D. Sh. Altman
author_facet	E. D. Altman A. V. Zurochka S. N. Teplova E. V. Davydova D. Sh. Altman
author_sort	E. D. Altman
title	CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS
title_short	CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS
title_full	CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS
title_fullStr	CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS
title_full_unstemmed	CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS
title_sort	characteristics of cellular and serum components of muco-salivary immune compartment in mature, aged, and senescent persons
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/eb5048d8f7524cad929cd4753282fec5
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CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS

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