Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

Rheumatoid arthritis is an inflammatory disease that selectively affects different joints. Here the authors show that gene expression and DNA methylation patterns of fibroblast-like synoviocytes differ between hip and knee joints in patients with RA, thus providing epigenetic and transcriptomic evid...

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Autores principales:	Rizi Ai, Deepa Hammaker, David L. Boyle, Rachel Morgan, Alice M. Walsh, Shicai Fan, Gary S. Firestein, Wei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb5348bb5d1d45878fc5cfd1521dc464
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spelling	oai:doaj.org-article:eb5348bb5d1d45878fc5cfd1521dc4642021-12-02T17:32:07ZJoint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes10.1038/ncomms118492041-1723https://doaj.org/article/eb5348bb5d1d45878fc5cfd1521dc4642016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11849https://doaj.org/toc/2041-1723Rheumatoid arthritis is an inflammatory disease that selectively affects different joints. Here the authors show that gene expression and DNA methylation patterns of fibroblast-like synoviocytes differ between hip and knee joints in patients with RA, thus providing epigenetic and transcriptomic evidence for this anatomic selectivity of inflammation.Rizi AiDeepa HammakerDavid L. BoyleRachel MorganAlice M. WalshShicai FanGary S. FiresteinWei WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rizi Ai Deepa Hammaker David L. Boyle Rachel Morgan Alice M. Walsh Shicai Fan Gary S. Firestein Wei Wang Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
description	Rheumatoid arthritis is an inflammatory disease that selectively affects different joints. Here the authors show that gene expression and DNA methylation patterns of fibroblast-like synoviocytes differ between hip and knee joints in patients with RA, thus providing epigenetic and transcriptomic evidence for this anatomic selectivity of inflammation.
format	article
author	Rizi Ai Deepa Hammaker David L. Boyle Rachel Morgan Alice M. Walsh Shicai Fan Gary S. Firestein Wei Wang
author_facet	Rizi Ai Deepa Hammaker David L. Boyle Rachel Morgan Alice M. Walsh Shicai Fan Gary S. Firestein Wei Wang
author_sort	Rizi Ai
title	Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
title_short	Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
title_full	Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
title_fullStr	Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
title_full_unstemmed	Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
title_sort	joint-specific dna methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/eb5348bb5d1d45878fc5cfd1521dc464
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Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

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