Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

Rheumatoid arthritis is an inflammatory disease that selectively affects different joints. Here the authors show that gene expression and DNA methylation patterns of fibroblast-like synoviocytes differ between hip and knee joints in patients with RA, thus providing epigenetic and transcriptomic evid...

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Bibliographic Details
Main Authors: Rizi Ai, Deepa Hammaker, David L. Boyle, Rachel Morgan, Alice M. Walsh, Shicai Fan, Gary S. Firestein, Wei Wang
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/eb5348bb5d1d45878fc5cfd1521dc464
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