Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe

Abstract Early diagnosis and therapy of liver fibrosis is of utmost importance, especially considering the increased incidence of alcoholic and non-alcoholic liver syndromes. In this work, a systematic study is reported to develop a dual function and biocompatible nanoprobe for liver specific diagno...

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Autores principales:	Ariya Saraswathy, Shaiju S. Nazeer, Nirmala Nimi, Hema Santhakumar, Parvathy Radhakrishnapillai Suma, Kunnumpurathu Jibin, Marina Victor, Francis Boniface Fernandez, Sabareeswaran Arumugam, Sachin J. Shenoy, P. R. Harikrishna Varma, Ramapurath S. Jayasree
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb569e0212e0444aa45bc46b1934a868
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spelling	oai:doaj.org-article:eb569e0212e0444aa45bc46b1934a8682021-12-02T17:23:46ZAsialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe10.1038/s41598-021-97808-02045-2322https://doaj.org/article/eb569e0212e0444aa45bc46b1934a8682021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97808-0https://doaj.org/toc/2045-2322Abstract Early diagnosis and therapy of liver fibrosis is of utmost importance, especially considering the increased incidence of alcoholic and non-alcoholic liver syndromes. In this work, a systematic study is reported to develop a dual function and biocompatible nanoprobe for liver specific diagnostic and therapeutic applications. A polysaccharide polymer, pullulan stabilized iron oxide nanoparticle (P-SPIONs) enabled high liver specificity via asialogycoprotein receptor mediation. Longitudinal and transverse magnetic relaxation rates of 2.15 and 146.91 mM−1 s−1 respectively and a size of 12 nm, confirmed the T2 weighted magnetic resonance imaging (MRI) efficacy of P-SPIONs. A current of 400A on 5 mg/ml of P-SPIONs raised the temperature above 50 °C, to facilitate effective hyperthermia. Finally, a NIR dye conjugation facilitated targeted dual imaging in liver fibrosis models, in vivo, with favourable histopathological results and recommends its use in early stage diagnosis using MRI and optical imaging, and subsequent therapy using hyperthermia.Ariya SaraswathyShaiju S. NazeerNirmala NimiHema SanthakumarParvathy Radhakrishnapillai SumaKunnumpurathu JibinMarina VictorFrancis Boniface FernandezSabareeswaran ArumugamSachin J. ShenoyP. R. Harikrishna VarmaRamapurath S. JayasreeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ariya Saraswathy Shaiju S. Nazeer Nirmala Nimi Hema Santhakumar Parvathy Radhakrishnapillai Suma Kunnumpurathu Jibin Marina Victor Francis Boniface Fernandez Sabareeswaran Arumugam Sachin J. Shenoy P. R. Harikrishna Varma Ramapurath S. Jayasree Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe
description	Abstract Early diagnosis and therapy of liver fibrosis is of utmost importance, especially considering the increased incidence of alcoholic and non-alcoholic liver syndromes. In this work, a systematic study is reported to develop a dual function and biocompatible nanoprobe for liver specific diagnostic and therapeutic applications. A polysaccharide polymer, pullulan stabilized iron oxide nanoparticle (P-SPIONs) enabled high liver specificity via asialogycoprotein receptor mediation. Longitudinal and transverse magnetic relaxation rates of 2.15 and 146.91 mM−1 s−1 respectively and a size of 12 nm, confirmed the T2 weighted magnetic resonance imaging (MRI) efficacy of P-SPIONs. A current of 400A on 5 mg/ml of P-SPIONs raised the temperature above 50 °C, to facilitate effective hyperthermia. Finally, a NIR dye conjugation facilitated targeted dual imaging in liver fibrosis models, in vivo, with favourable histopathological results and recommends its use in early stage diagnosis using MRI and optical imaging, and subsequent therapy using hyperthermia.
format	article
author	Ariya Saraswathy Shaiju S. Nazeer Nirmala Nimi Hema Santhakumar Parvathy Radhakrishnapillai Suma Kunnumpurathu Jibin Marina Victor Francis Boniface Fernandez Sabareeswaran Arumugam Sachin J. Shenoy P. R. Harikrishna Varma Ramapurath S. Jayasree
author_facet	Ariya Saraswathy Shaiju S. Nazeer Nirmala Nimi Hema Santhakumar Parvathy Radhakrishnapillai Suma Kunnumpurathu Jibin Marina Victor Francis Boniface Fernandez Sabareeswaran Arumugam Sachin J. Shenoy P. R. Harikrishna Varma Ramapurath S. Jayasree
author_sort	Ariya Saraswathy
title	Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe
title_short	Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe
title_full	Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe
title_fullStr	Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe
title_full_unstemmed	Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe
title_sort	asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb569e0212e0444aa45bc46b1934a868
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Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe

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