The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol

Abstract Background Bipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental dis...

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Autores principales:	Christoph Vogelbacher, Jens Sommer, Verena Schuster, Miriam H. A. Bopp, Irina Falkenberg, Philipp S. Ritter, Felix Bermpohl, Catherine Hindi Attar, Lisa Rauer, Karolin E. Einenkel, Jens Treutlein, Oliver Gruber, Georg Juckel, Vera Flasbeck, Christoph Mulert, Martin Hautzinger, Andrea Pfennig, Silke Matura, Andreas Reif, Dominik Grotegerd, Udo Dannlowski, Tilo Kircher, Michael Bauer, Andreas Jansen
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	BipoLife Bipolar disorder Major depression fMRI MRI quality assurance Multicenter study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/eb5d9706b6574112bd0f4a0f6c533da6
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spelling	oai:doaj.org-article:eb5d9706b6574112bd0f4a0f6c533da62021-11-21T12:12:01ZThe German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol10.1186/s40345-021-00240-62194-7511https://doaj.org/article/eb5d9706b6574112bd0f4a0f6c533da62021-11-01T00:00:00Zhttps://doi.org/10.1186/s40345-021-00240-6https://doaj.org/toc/2194-7511Abstract Background Bipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental disorders, the mechanisms underlying bipolar disorder at the neural network level still remain elusive. This has severe consequences for clinical practice, for instance by inadequate diagnoses or delayed treatments. The German research consortium BipoLife aims to shed light on the mechanisms underlying bipolar disorders. It was established in 2015 and incorporates ten university hospitals across Germany. Its research projects focus in particular on individuals at high risk of bipolar disorder, young patients in the early stages of the disease and patients with an unstable highly relapsing course and/or with acute suicidal ideation. Methods Functional and structural magnetic resonance imaging (MRI) data was acquired across nine sites within three different studies. Obtaining neuroimaging data in a multicenter setting requires among others the harmonization of the acquisition protocol, the standardization of paradigms and the implementation of regular quality control procedures. The present article outlines the MRI imaging protocols, the acquisition parameters, the imaging paradigms, the neuroimaging quality assessment procedures and the number of recruited subjects. Discussion The careful implementation of a MRI study protocol as well as the adherence to well-defined quality assessment procedures is one key benchmark in the evaluation of the overall quality of large-scale multicenter imaging studies. This article contributes to the BipoLife project by outlining the rationale and the design of the MRI study protocol. It helps to set the necessary standards for follow-up analyses and provides the technical details for an in-depth understanding of follow-up publications.Christoph VogelbacherJens SommerVerena SchusterMiriam H. A. BoppIrina FalkenbergPhilipp S. RitterFelix BermpohlCatherine Hindi AttarLisa RauerKarolin E. EinenkelJens TreutleinOliver GruberGeorg JuckelVera FlasbeckChristoph MulertMartin HautzingerAndrea PfennigSilke MaturaAndreas ReifDominik GrotegerdUdo DannlowskiTilo KircherMichael BauerAndreas JansenSpringerOpenarticleBipoLifeBipolar disorderMajor depressionfMRIMRI quality assuranceMulticenter studyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurophysiology and neuropsychologyQP351-495ENInternational Journal of Bipolar Disorders, Vol 9, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BipoLife Bipolar disorder Major depression fMRI MRI quality assurance Multicenter study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	BipoLife Bipolar disorder Major depression fMRI MRI quality assurance Multicenter study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495 Christoph Vogelbacher Jens Sommer Verena Schuster Miriam H. A. Bopp Irina Falkenberg Philipp S. Ritter Felix Bermpohl Catherine Hindi Attar Lisa Rauer Karolin E. Einenkel Jens Treutlein Oliver Gruber Georg Juckel Vera Flasbeck Christoph Mulert Martin Hautzinger Andrea Pfennig Silke Matura Andreas Reif Dominik Grotegerd Udo Dannlowski Tilo Kircher Michael Bauer Andreas Jansen The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol
description	Abstract Background Bipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental disorders, the mechanisms underlying bipolar disorder at the neural network level still remain elusive. This has severe consequences for clinical practice, for instance by inadequate diagnoses or delayed treatments. The German research consortium BipoLife aims to shed light on the mechanisms underlying bipolar disorders. It was established in 2015 and incorporates ten university hospitals across Germany. Its research projects focus in particular on individuals at high risk of bipolar disorder, young patients in the early stages of the disease and patients with an unstable highly relapsing course and/or with acute suicidal ideation. Methods Functional and structural magnetic resonance imaging (MRI) data was acquired across nine sites within three different studies. Obtaining neuroimaging data in a multicenter setting requires among others the harmonization of the acquisition protocol, the standardization of paradigms and the implementation of regular quality control procedures. The present article outlines the MRI imaging protocols, the acquisition parameters, the imaging paradigms, the neuroimaging quality assessment procedures and the number of recruited subjects. Discussion The careful implementation of a MRI study protocol as well as the adherence to well-defined quality assessment procedures is one key benchmark in the evaluation of the overall quality of large-scale multicenter imaging studies. This article contributes to the BipoLife project by outlining the rationale and the design of the MRI study protocol. It helps to set the necessary standards for follow-up analyses and provides the technical details for an in-depth understanding of follow-up publications.
format	article
author	Christoph Vogelbacher Jens Sommer Verena Schuster Miriam H. A. Bopp Irina Falkenberg Philipp S. Ritter Felix Bermpohl Catherine Hindi Attar Lisa Rauer Karolin E. Einenkel Jens Treutlein Oliver Gruber Georg Juckel Vera Flasbeck Christoph Mulert Martin Hautzinger Andrea Pfennig Silke Matura Andreas Reif Dominik Grotegerd Udo Dannlowski Tilo Kircher Michael Bauer Andreas Jansen
author_facet	Christoph Vogelbacher Jens Sommer Verena Schuster Miriam H. A. Bopp Irina Falkenberg Philipp S. Ritter Felix Bermpohl Catherine Hindi Attar Lisa Rauer Karolin E. Einenkel Jens Treutlein Oliver Gruber Georg Juckel Vera Flasbeck Christoph Mulert Martin Hautzinger Andrea Pfennig Silke Matura Andreas Reif Dominik Grotegerd Udo Dannlowski Tilo Kircher Michael Bauer Andreas Jansen
author_sort	Christoph Vogelbacher
title	The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol
title_short	The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol
title_full	The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol
title_fullStr	The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol
title_full_unstemmed	The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol
title_sort	german research consortium for the study of bipolar disorder (bipolife): a magnetic resonance imaging study protocol
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/eb5d9706b6574112bd0f4a0f6c533da6
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The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol

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