SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.

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Autores principales:	Nanda Kishore Routhu, Narayanaiah Cheedarla, Venkata Satish Bollimpelli, Sailaja Gangadhara, Venkata Viswanadh Edara, Lilin Lai, Anusmita Sahoo, Ayalnesh Shiferaw, Tiffany M. Styles, Katharine Floyd, Stephanie Fischinger, Caroline Atyeo, Sally A. Shin, Sanjeev Gumber, Shannon Kirejczyk, Kenneth H. Dinnon, Pei-Yong Shi, Vineet D. Menachery, Mark Tomai, Christopher B. Fox, Galit Alter, Thomas H. Vanderford, Lisa Gralinski, Mehul S. Suthar, Rama Rao Amara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb5e727593c442beadc6bb289092f047
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spelling	oai:doaj.org-article:eb5e727593c442beadc6bb289092f0472021-12-02T17:52:38ZSARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung10.1038/s41467-021-23942-y2041-1723https://doaj.org/article/eb5e727593c442beadc6bb289092f0472021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23942-yhttps://doaj.org/toc/2041-1723Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.Nanda Kishore RouthuNarayanaiah CheedarlaVenkata Satish BollimpelliSailaja GangadharaVenkata Viswanadh EdaraLilin LaiAnusmita SahooAyalnesh ShiferawTiffany M. StylesKatharine FloydStephanie FischingerCaroline AtyeoSally A. ShinSanjeev GumberShannon KirejczykKenneth H. DinnonPei-Yong ShiVineet D. MenacheryMark TomaiChristopher B. FoxGalit AlterThomas H. VanderfordLisa GralinskiMehul S. SutharRama Rao AmaraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nanda Kishore Routhu Narayanaiah Cheedarla Venkata Satish Bollimpelli Sailaja Gangadhara Venkata Viswanadh Edara Lilin Lai Anusmita Sahoo Ayalnesh Shiferaw Tiffany M. Styles Katharine Floyd Stephanie Fischinger Caroline Atyeo Sally A. Shin Sanjeev Gumber Shannon Kirejczyk Kenneth H. Dinnon Pei-Yong Shi Vineet D. Menachery Mark Tomai Christopher B. Fox Galit Alter Thomas H. Vanderford Lisa Gralinski Mehul S. Suthar Rama Rao Amara SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
description	Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.
format	article
author	Nanda Kishore Routhu Narayanaiah Cheedarla Venkata Satish Bollimpelli Sailaja Gangadhara Venkata Viswanadh Edara Lilin Lai Anusmita Sahoo Ayalnesh Shiferaw Tiffany M. Styles Katharine Floyd Stephanie Fischinger Caroline Atyeo Sally A. Shin Sanjeev Gumber Shannon Kirejczyk Kenneth H. Dinnon Pei-Yong Shi Vineet D. Menachery Mark Tomai Christopher B. Fox Galit Alter Thomas H. Vanderford Lisa Gralinski Mehul S. Suthar Rama Rao Amara
author_facet	Nanda Kishore Routhu Narayanaiah Cheedarla Venkata Satish Bollimpelli Sailaja Gangadhara Venkata Viswanadh Edara Lilin Lai Anusmita Sahoo Ayalnesh Shiferaw Tiffany M. Styles Katharine Floyd Stephanie Fischinger Caroline Atyeo Sally A. Shin Sanjeev Gumber Shannon Kirejczyk Kenneth H. Dinnon Pei-Yong Shi Vineet D. Menachery Mark Tomai Christopher B. Fox Galit Alter Thomas H. Vanderford Lisa Gralinski Mehul S. Suthar Rama Rao Amara
author_sort	Nanda Kishore Routhu
title	SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
title_short	SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
title_full	SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
title_fullStr	SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
title_full_unstemmed	SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
title_sort	sars-cov-2 rbd trimer protein adjuvanted with alum-3m-052 protects from sars-cov-2 infection and immune pathology in the lung
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb5e727593c442beadc6bb289092f047
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SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

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