IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

The role of IFI16 as a DNA sensor is highly controversial. With support from aNature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.

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Autores principales:	Jessica F. Almine, Craig A. J. O’Hare, Gillian Dunphy, Ismar R. Haga, Rangeetha J. Naik, Abdelmadjid Atrih, Dympna J. Connolly, Jordan Taylor, Ian R. Kelsall, Andrew G. Bowie, Philippa M. Beard, Leonie Unterholzner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb5ed45912da4959a911474e177edfb0
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spelling	oai:doaj.org-article:eb5ed45912da4959a911474e177edfb02021-12-02T15:39:05ZIFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes10.1038/ncomms143922041-1723https://doaj.org/article/eb5ed45912da4959a911474e177edfb02017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14392https://doaj.org/toc/2041-1723The role of IFI16 as a DNA sensor is highly controversial. With support from aNature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.Jessica F. AlmineCraig A. J. O’HareGillian DunphyIsmar R. HagaRangeetha J. NaikAbdelmadjid AtrihDympna J. ConnollyJordan TaylorIan R. KelsallAndrew G. BowiePhilippa M. BeardLeonie UnterholznerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica F. Almine Craig A. J. O’Hare Gillian Dunphy Ismar R. Haga Rangeetha J. Naik Abdelmadjid Atrih Dympna J. Connolly Jordan Taylor Ian R. Kelsall Andrew G. Bowie Philippa M. Beard Leonie Unterholzner IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
description	The role of IFI16 as a DNA sensor is highly controversial. With support from aNature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.
format	article
author	Jessica F. Almine Craig A. J. O’Hare Gillian Dunphy Ismar R. Haga Rangeetha J. Naik Abdelmadjid Atrih Dympna J. Connolly Jordan Taylor Ian R. Kelsall Andrew G. Bowie Philippa M. Beard Leonie Unterholzner
author_facet	Jessica F. Almine Craig A. J. O’Hare Gillian Dunphy Ismar R. Haga Rangeetha J. Naik Abdelmadjid Atrih Dympna J. Connolly Jordan Taylor Ian R. Kelsall Andrew G. Bowie Philippa M. Beard Leonie Unterholzner
author_sort	Jessica F. Almine
title	IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
title_short	IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
title_full	IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
title_fullStr	IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
title_full_unstemmed	IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
title_sort	ifi16 and cgas cooperate in the activation of sting during dna sensing in human keratinocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eb5ed45912da4959a911474e177edfb0
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IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

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