IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
The role of IFI16 as a DNA sensor is highly controversial. With support from aNature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.
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Autores principales: | Jessica F. Almine, Craig A. J. O’Hare, Gillian Dunphy, Ismar R. Haga, Rangeetha J. Naik, Abdelmadjid Atrih, Dympna J. Connolly, Jordan Taylor, Ian R. Kelsall, Andrew G. Bowie, Philippa M. Beard, Leonie Unterholzner |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/eb5ed45912da4959a911474e177edfb0 |
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