The physiology of cardiovascular disease and innovative liposomal platforms for therapy

The physiology of cardiovascular disease and innovative liposomal platforms for therapy

Guillermo U Ruiz-Esparza,1,3 Jose H Flores-Arredondo,2 Victor Segura-Ibarra,3 Guillermo Torre-Amione,2,3 Mauro Ferrari,1 Elvin Blanco,1,* Rita E Serda1,3,* 1Methodist Hospital Research Institute, 2Methodist DeBakey Heart and Vascular Center, Methodist Hospital, Houston, TX, USA; 3Escuela de Medicina...

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Autores principales: Ruiz-Esparza GU, Flores-Arredondo JH, Segura-Ibarra V, Torre-Amione G, Ferrari M, Blanco E, Serda RE
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/eb60662a0b1e4134b7edf6a507d6afa9
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spelling oai:doaj.org-article:eb60662a0b1e4134b7edf6a507d6afa92021-12-02T05:58:07ZThe physiology of cardiovascular disease and innovative liposomal platforms for therapy1176-91141178-2013https://doaj.org/article/eb60662a0b1e4134b7edf6a507d6afa92013-02-01T00:00:00Zhttp://www.dovepress.com/the-physiology-of-cardiovascular-disease-and-innovative-liposomal-plat-a12168https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Guillermo U Ruiz-Esparza,1,3 Jose H Flores-Arredondo,2 Victor Segura-Ibarra,3 Guillermo Torre-Amione,2,3 Mauro Ferrari,1 Elvin Blanco,1,* Rita E Serda1,3,* 1Methodist Hospital Research Institute, 2Methodist DeBakey Heart and Vascular Center, Methodist Hospital, Houston, TX, USA; 3Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico *Senior authors Abstract: Heart disease remains the major cause of death in males and females, emphasizing the need for novel strategies to improve patient treatment and survival. A therapeutic approach, still in its infancy, is the development of site-specific drug-delivery systems. Nanoparticle-based delivery systems, such as liposomes, have evolved into robust platforms for site-specific delivery of therapeutics. In this review, the clinical impact of cardiovascular disease and the pathophysiology of different subsets of the disease are described. Potential pathological targets for therapy are introduced, and promising advances in nanotherapeutic cardiovascular applications involving liposomal platforms are presented. Keywords: liposomes, cardiovascular disease, therapeutics, nanoparticles, nanomedicineRuiz-Esparza GUFlores-Arredondo JHSegura-Ibarra VTorre-Amione GFerrari MBlanco ESerda REDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 629-640 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Ruiz-Esparza GU
Flores-Arredondo JH
Segura-Ibarra V
Torre-Amione G
Ferrari M
Blanco E
Serda RE
The physiology of cardiovascular disease and innovative liposomal platforms for therapy
description Guillermo U Ruiz-Esparza,1,3 Jose H Flores-Arredondo,2 Victor Segura-Ibarra,3 Guillermo Torre-Amione,2,3 Mauro Ferrari,1 Elvin Blanco,1,* Rita E Serda1,3,* 1Methodist Hospital Research Institute, 2Methodist DeBakey Heart and Vascular Center, Methodist Hospital, Houston, TX, USA; 3Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico *Senior authors Abstract: Heart disease remains the major cause of death in males and females, emphasizing the need for novel strategies to improve patient treatment and survival. A therapeutic approach, still in its infancy, is the development of site-specific drug-delivery systems. Nanoparticle-based delivery systems, such as liposomes, have evolved into robust platforms for site-specific delivery of therapeutics. In this review, the clinical impact of cardiovascular disease and the pathophysiology of different subsets of the disease are described. Potential pathological targets for therapy are introduced, and promising advances in nanotherapeutic cardiovascular applications involving liposomal platforms are presented. Keywords: liposomes, cardiovascular disease, therapeutics, nanoparticles, nanomedicine
format article
author Ruiz-Esparza GU
Flores-Arredondo JH
Segura-Ibarra V
Torre-Amione G
Ferrari M
Blanco E
Serda RE
author_facet Ruiz-Esparza GU
Flores-Arredondo JH
Segura-Ibarra V
Torre-Amione G
Ferrari M
Blanco E
Serda RE
author_sort Ruiz-Esparza GU
title The physiology of cardiovascular disease and innovative liposomal platforms for therapy
title_short The physiology of cardiovascular disease and innovative liposomal platforms for therapy
title_full The physiology of cardiovascular disease and innovative liposomal platforms for therapy
title_fullStr The physiology of cardiovascular disease and innovative liposomal platforms for therapy
title_full_unstemmed The physiology of cardiovascular disease and innovative liposomal platforms for therapy
title_sort physiology of cardiovascular disease and innovative liposomal platforms for therapy
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/eb60662a0b1e4134b7edf6a507d6afa9
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