ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells

IL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and functi...

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Autores principales:	Weishan Huang, Sabrina Solouki, Nicholas Koylass, Song-Guo Zheng, Avery August
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb63136b19fd40fbb0f60255832a0ecd
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spelling	oai:doaj.org-article:eb63136b19fd40fbb0f60255832a0ecd2021-12-02T17:06:17ZITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells10.1038/ncomms158712041-1723https://doaj.org/article/eb63136b19fd40fbb0f60255832a0ecd2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15871https://doaj.org/toc/2041-1723IL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and function of Tr1 cells.Weishan HuangSabrina SoloukiNicholas KoylassSong-Guo ZhengAvery AugustNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weishan Huang Sabrina Solouki Nicholas Koylass Song-Guo Zheng Avery August ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
description	IL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and function of Tr1 cells.
format	article
author	Weishan Huang Sabrina Solouki Nicholas Koylass Song-Guo Zheng Avery August
author_facet	Weishan Huang Sabrina Solouki Nicholas Koylass Song-Guo Zheng Avery August
author_sort	Weishan Huang
title	ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_short	ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_full	ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_fullStr	ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_full_unstemmed	ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_sort	itk signalling via the ras/irf4 pathway regulates the development and function of tr1 cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eb63136b19fd40fbb0f60255832a0ecd
work_keys_str_mv	AT weishanhuang itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells AT sabrinasolouki itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells AT nicholaskoylass itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells AT songguozheng itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells AT averyaugust itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells
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ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells

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