Reactivation of a developmentally silenced embryonic globin gene

Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super-enhancer, and zeta-globin can be reactivated by a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb63b89aa9ae4973bb86a64000a9ce01
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb63b89aa9ae4973bb86a64000a9ce01
record_format	dspace
spelling	oai:doaj.org-article:eb63b89aa9ae4973bb86a64000a9ce012021-12-02T16:26:25ZReactivation of a developmentally silenced embryonic globin gene10.1038/s41467-021-24402-32041-1723https://doaj.org/article/eb63b89aa9ae4973bb86a64000a9ce012021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24402-3https://doaj.org/toc/2041-1723Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super-enhancer, and zeta-globin can be reactivated by acetylation.Andrew J. KingDuantida SongdejDamien J. DownesRobert A. BeagrieSiyu LiuMegan BuckleyPeng HuaMaria C. SuciuA. Marieke OudelaarLars L. P. HanssenDanuta JeziorskaNigel RobertsStephanie J. CarpenterHelena FrancisJelena TeleniusAude-Anais OlijnikJacqueline A. SharpeJacqueline Sloane-StanleyJennifer EglintonMira T. KassoufStuart H. OrkinLen A. PennacchioJames O. J. DaviesJim R. HughesDouglas R. HiggsChristian BabbsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew J. King Duantida Songdej Damien J. Downes Robert A. Beagrie Siyu Liu Megan Buckley Peng Hua Maria C. Suciu A. Marieke Oudelaar Lars L. P. Hanssen Danuta Jeziorska Nigel Roberts Stephanie J. Carpenter Helena Francis Jelena Telenius Aude-Anais Olijnik Jacqueline A. Sharpe Jacqueline Sloane-Stanley Jennifer Eglinton Mira T. Kassouf Stuart H. Orkin Len A. Pennacchio James O. J. Davies Jim R. Hughes Douglas R. Higgs Christian Babbs Reactivation of a developmentally silenced embryonic globin gene
description	Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super-enhancer, and zeta-globin can be reactivated by acetylation.
format	article
author	Andrew J. King Duantida Songdej Damien J. Downes Robert A. Beagrie Siyu Liu Megan Buckley Peng Hua Maria C. Suciu A. Marieke Oudelaar Lars L. P. Hanssen Danuta Jeziorska Nigel Roberts Stephanie J. Carpenter Helena Francis Jelena Telenius Aude-Anais Olijnik Jacqueline A. Sharpe Jacqueline Sloane-Stanley Jennifer Eglinton Mira T. Kassouf Stuart H. Orkin Len A. Pennacchio James O. J. Davies Jim R. Hughes Douglas R. Higgs Christian Babbs
author_facet	Andrew J. King Duantida Songdej Damien J. Downes Robert A. Beagrie Siyu Liu Megan Buckley Peng Hua Maria C. Suciu A. Marieke Oudelaar Lars L. P. Hanssen Danuta Jeziorska Nigel Roberts Stephanie J. Carpenter Helena Francis Jelena Telenius Aude-Anais Olijnik Jacqueline A. Sharpe Jacqueline Sloane-Stanley Jennifer Eglinton Mira T. Kassouf Stuart H. Orkin Len A. Pennacchio James O. J. Davies Jim R. Hughes Douglas R. Higgs Christian Babbs
author_sort	Andrew J. King
title	Reactivation of a developmentally silenced embryonic globin gene
title_short	Reactivation of a developmentally silenced embryonic globin gene
title_full	Reactivation of a developmentally silenced embryonic globin gene
title_fullStr	Reactivation of a developmentally silenced embryonic globin gene
title_full_unstemmed	Reactivation of a developmentally silenced embryonic globin gene
title_sort	reactivation of a developmentally silenced embryonic globin gene
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb63b89aa9ae4973bb86a64000a9ce01
work_keys_str_mv	AT andrewjking reactivationofadevelopmentallysilencedembryonicglobingene AT duantidasongdej reactivationofadevelopmentallysilencedembryonicglobingene AT damienjdownes reactivationofadevelopmentallysilencedembryonicglobingene AT robertabeagrie reactivationofadevelopmentallysilencedembryonicglobingene AT siyuliu reactivationofadevelopmentallysilencedembryonicglobingene AT meganbuckley reactivationofadevelopmentallysilencedembryonicglobingene AT penghua reactivationofadevelopmentallysilencedembryonicglobingene AT mariacsuciu reactivationofadevelopmentallysilencedembryonicglobingene AT amariekeoudelaar reactivationofadevelopmentallysilencedembryonicglobingene AT larslphanssen reactivationofadevelopmentallysilencedembryonicglobingene AT danutajeziorska reactivationofadevelopmentallysilencedembryonicglobingene AT nigelroberts reactivationofadevelopmentallysilencedembryonicglobingene AT stephaniejcarpenter reactivationofadevelopmentallysilencedembryonicglobingene AT helenafrancis reactivationofadevelopmentallysilencedembryonicglobingene AT jelenatelenius reactivationofadevelopmentallysilencedembryonicglobingene AT audeanaisolijnik reactivationofadevelopmentallysilencedembryonicglobingene AT jacquelineasharpe reactivationofadevelopmentallysilencedembryonicglobingene AT jacquelinesloanestanley reactivationofadevelopmentallysilencedembryonicglobingene AT jennifereglinton reactivationofadevelopmentallysilencedembryonicglobingene AT miratkassouf reactivationofadevelopmentallysilencedembryonicglobingene AT stuarthorkin reactivationofadevelopmentallysilencedembryonicglobingene AT lenapennacchio reactivationofadevelopmentallysilencedembryonicglobingene AT jamesojdavies reactivationofadevelopmentallysilencedembryonicglobingene AT jimrhughes reactivationofadevelopmentallysilencedembryonicglobingene AT douglasrhiggs reactivationofadevelopmentallysilencedembryonicglobingene AT christianbabbs reactivationofadevelopmentallysilencedembryonicglobingene
_version_	1718384088718508032

Reactivation of a developmentally silenced embryonic globin gene

Ejemplares similares