Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel

Abstract For human dental enamel, what is the precise mineralization progression spatially and the precise timing of mineralization? This is an important question in the fundamental understanding of matrix-mediated biomineralization events, but in particular because we can use our understanding of t...

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Autores principales:	Mohammed Al-Mosawi, Graham Roy Davis, Andy Bushby, Janet Montgomery, Julia Beaumont, Maisoon Al-Jawad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Texture Magnitude Prism Boundaries Human Enamel Prism Cores Labial Enamel Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb68342768a04c72aaead64d8c91d198
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spelling	oai:doaj.org-article:eb68342768a04c72aaead64d8c91d1982021-12-02T11:41:24ZCrystallographic texture and mineral concentration quantification of developing and mature human incisal enamel10.1038/s41598-018-32425-y2045-2322https://doaj.org/article/eb68342768a04c72aaead64d8c91d1982018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32425-yhttps://doaj.org/toc/2045-2322Abstract For human dental enamel, what is the precise mineralization progression spatially and the precise timing of mineralization? This is an important question in the fundamental understanding of matrix-mediated biomineralization events, but in particular because we can use our understanding of this natural tissue growth in humans to develop biomimetic approaches to repair and replace lost enamel tissue. It is important to understand human tissues in particular since different species have quite distinct spatial and temporal progression of mineralization. In this study, five human central incisors at different stages of enamel maturation/mineralization were spatially mapped using synchrotron X-ray diffraction and X-ray microtomography techniques. From the earliest developmental stage, two crystallite-orientation populations coexist with angular separations between the crystallite populations of approximately 40° varying as a function of position within the tooth crown. In general, one population had significantly lower texture magnitude and contributed a higher percentage to the overall crystalline structure, compared to the other population which contributed only 20–30% but had significantly higher texture magnitude. This quantitative analysis allows us to understand the complex and co-operative structure-function relationship between two populations of crystallites within human enamel. There was an increase in the mineral concentration from the enamel-dentin junction peripherally and from the incisal tip cervically as a function of maturation time. Quantitative backscattered-electron analyses showed that mineralization of prism cores precedes that of prism boundaries. These results provide new insights into the precise understanding of the natural growth of human enamel.Mohammed Al-MosawiGraham Roy DavisAndy BushbyJanet MontgomeryJulia BeaumontMaisoon Al-JawadNature PortfolioarticleTexture MagnitudePrism BoundariesHuman EnamelPrism CoresLabial EnamelMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Texture Magnitude Prism Boundaries Human Enamel Prism Cores Labial Enamel Medicine R Science Q
spellingShingle	Texture Magnitude Prism Boundaries Human Enamel Prism Cores Labial Enamel Medicine R Science Q Mohammed Al-Mosawi Graham Roy Davis Andy Bushby Janet Montgomery Julia Beaumont Maisoon Al-Jawad Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
description	Abstract For human dental enamel, what is the precise mineralization progression spatially and the precise timing of mineralization? This is an important question in the fundamental understanding of matrix-mediated biomineralization events, but in particular because we can use our understanding of this natural tissue growth in humans to develop biomimetic approaches to repair and replace lost enamel tissue. It is important to understand human tissues in particular since different species have quite distinct spatial and temporal progression of mineralization. In this study, five human central incisors at different stages of enamel maturation/mineralization were spatially mapped using synchrotron X-ray diffraction and X-ray microtomography techniques. From the earliest developmental stage, two crystallite-orientation populations coexist with angular separations between the crystallite populations of approximately 40° varying as a function of position within the tooth crown. In general, one population had significantly lower texture magnitude and contributed a higher percentage to the overall crystalline structure, compared to the other population which contributed only 20–30% but had significantly higher texture magnitude. This quantitative analysis allows us to understand the complex and co-operative structure-function relationship between two populations of crystallites within human enamel. There was an increase in the mineral concentration from the enamel-dentin junction peripherally and from the incisal tip cervically as a function of maturation time. Quantitative backscattered-electron analyses showed that mineralization of prism cores precedes that of prism boundaries. These results provide new insights into the precise understanding of the natural growth of human enamel.
format	article
author	Mohammed Al-Mosawi Graham Roy Davis Andy Bushby Janet Montgomery Julia Beaumont Maisoon Al-Jawad
author_facet	Mohammed Al-Mosawi Graham Roy Davis Andy Bushby Janet Montgomery Julia Beaumont Maisoon Al-Jawad
author_sort	Mohammed Al-Mosawi
title	Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
title_short	Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
title_full	Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
title_fullStr	Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
title_full_unstemmed	Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
title_sort	crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eb68342768a04c72aaead64d8c91d198
work_keys_str_mv	AT mohammedalmosawi crystallographictextureandmineralconcentrationquantificationofdevelopingandmaturehumanincisalenamel AT grahamroydavis crystallographictextureandmineralconcentrationquantificationofdevelopingandmaturehumanincisalenamel AT andybushby crystallographictextureandmineralconcentrationquantificationofdevelopingandmaturehumanincisalenamel AT janetmontgomery crystallographictextureandmineralconcentrationquantificationofdevelopingandmaturehumanincisalenamel AT juliabeaumont crystallographictextureandmineralconcentrationquantificationofdevelopingandmaturehumanincisalenamel AT maisoonaljawad crystallographictextureandmineralconcentrationquantificationofdevelopingandmaturehumanincisalenamel
_version_	1718395434840358912

Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel

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