Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.

<h4>Purpose</h4>To investigate the prognostic value of intratumoral invariant natural killer T (iNKT) cells and interferon-gamma (IFN-γ) in hepatocellular carcinoma (HCC) after curative resection.<h4>Experimental design</h4>Expression of TRAV10, encoding the Vα24 domain of iN...

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Autores principales:	Yong-Sheng Xiao, Qiang Gao, Xiang-Nan Xu, Yi-Wei Li, Min-Jie Ju, Ming-Yan Cai, Chen-Xin Dai, Jie Hu, Shuang-Jian Qiu, Jian Zhou, Jia Fan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb68f4053236436a841d77b31cc58687
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spelling	oai:doaj.org-article:eb68f4053236436a841d77b31cc586872021-11-18T09:01:23ZCombination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.1932-620310.1371/journal.pone.0070345https://doaj.org/article/eb68f4053236436a841d77b31cc586872013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23940564/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate the prognostic value of intratumoral invariant natural killer T (iNKT) cells and interferon-gamma (IFN-γ) in hepatocellular carcinoma (HCC) after curative resection.<h4>Experimental design</h4>Expression of TRAV10, encoding the Vα24 domain of iNKT cells, and IFN-γ mRNA were assessed by quantitative real-time polymerase chain reaction in tumor from 224 HCC patients undergoing curative resection. The prognostic value of these two and other clinicopathologic factors was evaluated.<h4>Results</h4>Either intratumoral iNKT cells and IFN-γ alone or their combination was an independent prognostic factor for OS (P = 0.001) and RFS (P = 0.001) by multivariate Cox proportional hazards analysis. Patients with concurrent low levels of iNKT cells and IFN-γ had a hazard ratio (HR) of 2.784 for OS and 2.673 for RFS. The areas under the curve of iNKT cells, IFN-γand their combination were 0.618 vs 0.608 vs 0.654 for death and 0.591 vs 0.604 vs 0.633 for recurrence respectively by receiver operating characteristic curve analysis. The prognosis was the worst for HCC patients with concurrent low levels of iNKT cells and IFN-γ, which might be related with more advanced pTNM stage and more vascular invasion.<h4>Conclusions</h4>Combination of intratumoral iNKT cells and IFN-γ is a promising independent predictor for recurrence and survival in HCC, which has a better power to predict HCC patients' outcome compared with intratumoral iNKT cells or IFN-γ alone.Yong-Sheng XiaoQiang GaoXiang-Nan XuYi-Wei LiMin-Jie JuMing-Yan CaiChen-Xin DaiJie HuShuang-Jian QiuJian ZhouJia FanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70345 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong-Sheng Xiao Qiang Gao Xiang-Nan Xu Yi-Wei Li Min-Jie Ju Ming-Yan Cai Chen-Xin Dai Jie Hu Shuang-Jian Qiu Jian Zhou Jia Fan Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
description	<h4>Purpose</h4>To investigate the prognostic value of intratumoral invariant natural killer T (iNKT) cells and interferon-gamma (IFN-γ) in hepatocellular carcinoma (HCC) after curative resection.<h4>Experimental design</h4>Expression of TRAV10, encoding the Vα24 domain of iNKT cells, and IFN-γ mRNA were assessed by quantitative real-time polymerase chain reaction in tumor from 224 HCC patients undergoing curative resection. The prognostic value of these two and other clinicopathologic factors was evaluated.<h4>Results</h4>Either intratumoral iNKT cells and IFN-γ alone or their combination was an independent prognostic factor for OS (P = 0.001) and RFS (P = 0.001) by multivariate Cox proportional hazards analysis. Patients with concurrent low levels of iNKT cells and IFN-γ had a hazard ratio (HR) of 2.784 for OS and 2.673 for RFS. The areas under the curve of iNKT cells, IFN-γand their combination were 0.618 vs 0.608 vs 0.654 for death and 0.591 vs 0.604 vs 0.633 for recurrence respectively by receiver operating characteristic curve analysis. The prognosis was the worst for HCC patients with concurrent low levels of iNKT cells and IFN-γ, which might be related with more advanced pTNM stage and more vascular invasion.<h4>Conclusions</h4>Combination of intratumoral iNKT cells and IFN-γ is a promising independent predictor for recurrence and survival in HCC, which has a better power to predict HCC patients' outcome compared with intratumoral iNKT cells or IFN-γ alone.
format	article
author	Yong-Sheng Xiao Qiang Gao Xiang-Nan Xu Yi-Wei Li Min-Jie Ju Ming-Yan Cai Chen-Xin Dai Jie Hu Shuang-Jian Qiu Jian Zhou Jia Fan
author_facet	Yong-Sheng Xiao Qiang Gao Xiang-Nan Xu Yi-Wei Li Min-Jie Ju Ming-Yan Cai Chen-Xin Dai Jie Hu Shuang-Jian Qiu Jian Zhou Jia Fan
author_sort	Yong-Sheng Xiao
title	Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
title_short	Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
title_full	Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
title_fullStr	Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
title_full_unstemmed	Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
title_sort	combination of intratumoral invariant natural killer t cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/eb68f4053236436a841d77b31cc58687
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Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.

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