Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil

Background/Aim. Phytochemical and pharmacological investigations of essential oils isolated from plant species of the genus Seseli have been intensified recently. These plant species have long-term use in nutrition and traditional medicine in the treatment of various disorders. Volatile secondary me...

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Autores principales:	Suručić Relja, Kundaković-Vasović Tatjana, Marčetić Mirjana, Drakul Dragana, Milenković Marina, Kovačević Nada
Formato:	article
Lenguaje:	EN SR
Publicado:	Military Health Department, Ministry of Defance, Serbia 2021
Materias:	apiaceae oils, volatile pharmacology plant extracts muscle relaxation antioxidants anti-infective agents Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eb6a8d5ae28c40fe926fbe989f571e11
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spelling	oai:doaj.org-article:eb6a8d5ae28c40fe926fbe989f571e112021-11-10T07:27:57ZPharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil0042-84502406-072010.2298/VSP190320028Shttps://doaj.org/article/eb6a8d5ae28c40fe926fbe989f571e112021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000028S.pdfhttps://doaj.org/toc/0042-8450https://doaj.org/toc/2406-0720Background/Aim. Phytochemical and pharmacological investigations of essential oils isolated from plant species of the genus Seseli have been intensified recently. These plant species have long-term use in nutrition and traditional medicine in the treatment of various disorders. Volatile secondary metabolites of Seseli gracile Waldst. & Kit (Apiaceae) have not been pharmacologically examined so far. The aim of the conducted research was to assess the antiradical, antimicrobial and spasmolytic activities of S. gracile essential oil isolated from the aerial parts of the plant. Methods. The antiradical activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test, antimicrobial activity using broth microdilution method with standard strains of Gram (+), Gram (-) bacteria and yeast, while spasmolytic activity was evaluated on isolated rat ileum, pre-contracted with a high concentration of potassium. Results. The results showed moderate antiradical (SC50 = 78.60 μg/mL) and good spasmolytic activity (IC50 = 271.4 nL/mL) of S. gracile essential oil. In the range of tested concentrations, minimal inhibitory concentration (MIC) was determined only for the strain of Escherichia coli (500 μg/mL). Conclusion. Results obtained in this study justify the need for further studies to elucidate exact molecular mechanism underlay this spasmolytic effect of S. gracile herb essential oil.Suručić ReljaKundaković-Vasović TatjanaMarčetić MirjanaDrakul DraganaMilenković MarinaKovačević NadaMilitary Health Department, Ministry of Defance, Serbiaarticleapiaceaeoils, volatilepharmacologyplant extractsmuscle relaxationantioxidantsanti-infective agentsMedicine (General)R5-920ENSRVojnosanitetski Pregled, Vol 78, Iss 10, Pp 1065-1071 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	apiaceae oils, volatile pharmacology plant extracts muscle relaxation antioxidants anti-infective agents Medicine (General) R5-920
spellingShingle	apiaceae oils, volatile pharmacology plant extracts muscle relaxation antioxidants anti-infective agents Medicine (General) R5-920 Suručić Relja Kundaković-Vasović Tatjana Marčetić Mirjana Drakul Dragana Milenković Marina Kovačević Nada Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil
description	Background/Aim. Phytochemical and pharmacological investigations of essential oils isolated from plant species of the genus Seseli have been intensified recently. These plant species have long-term use in nutrition and traditional medicine in the treatment of various disorders. Volatile secondary metabolites of Seseli gracile Waldst. & Kit (Apiaceae) have not been pharmacologically examined so far. The aim of the conducted research was to assess the antiradical, antimicrobial and spasmolytic activities of S. gracile essential oil isolated from the aerial parts of the plant. Methods. The antiradical activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test, antimicrobial activity using broth microdilution method with standard strains of Gram (+), Gram (-) bacteria and yeast, while spasmolytic activity was evaluated on isolated rat ileum, pre-contracted with a high concentration of potassium. Results. The results showed moderate antiradical (SC50 = 78.60 μg/mL) and good spasmolytic activity (IC50 = 271.4 nL/mL) of S. gracile essential oil. In the range of tested concentrations, minimal inhibitory concentration (MIC) was determined only for the strain of Escherichia coli (500 μg/mL). Conclusion. Results obtained in this study justify the need for further studies to elucidate exact molecular mechanism underlay this spasmolytic effect of S. gracile herb essential oil.
format	article
author	Suručić Relja Kundaković-Vasović Tatjana Marčetić Mirjana Drakul Dragana Milenković Marina Kovačević Nada
author_facet	Suručić Relja Kundaković-Vasović Tatjana Marčetić Mirjana Drakul Dragana Milenković Marina Kovačević Nada
author_sort	Suručić Relja
title	Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil
title_short	Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil
title_full	Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil
title_fullStr	Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil
title_full_unstemmed	Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil
title_sort	pharmacological characterisation of seseli gracile waldst. & kit (apiaceae) essential oil
publisher	Military Health Department, Ministry of Defance, Serbia
publishDate	2021
url	https://doaj.org/article/eb6a8d5ae28c40fe926fbe989f571e11
work_keys_str_mv	AT surucicrelja pharmacologicalcharacterisationofseseligracilewaldstkitapiaceaeessentialoil AT kundakovicvasovictatjana pharmacologicalcharacterisationofseseligracilewaldstkitapiaceaeessentialoil AT marceticmirjana pharmacologicalcharacterisationofseseligracilewaldstkitapiaceaeessentialoil AT drakuldragana pharmacologicalcharacterisationofseseligracilewaldstkitapiaceaeessentialoil AT milenkovicmarina pharmacologicalcharacterisationofseseligracilewaldstkitapiaceaeessentialoil AT kovacevicnada pharmacologicalcharacterisationofseseligracilewaldstkitapiaceaeessentialoil
_version_	1718440520111357952

Pharmacological characterisation of Seseli gracile Waldst. & Kit (Apiaceae) essential oil

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