ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS

Antimicrobial peptides are a heterogeneous group of molecules involved in the innate and acquired immune response of various organisms, ranging from prokaryotes to mammals, including humans. They consist of 12–50 amino acid residues; have different physico-chemical and biological properties. The mos...

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Autor principal:	Kh. G. Musin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Materias:	antimicrobial peptides innovative drugs immunopathology defensins cathelicidins antibiotics resistance Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/eb6d61543e0248dd91846bb55d8dcbcd
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spelling	oai:doaj.org-article:eb6d61543e0248dd91846bb55d8dcbcd2021-11-22T07:09:49ZANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS2220-76192313-739810.15789/2220-7619-2018-3-295-308https://doaj.org/article/eb6d61543e0248dd91846bb55d8dcbcd2018-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/779https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Antimicrobial peptides are a heterogeneous group of molecules involved in the innate and acquired immune response of various organisms, ranging from prokaryotes to mammals, including humans. They consist of 12–50 amino acid residues; have different physico-chemical and biological properties. The most common feature is their ability to destroy the prokaryotic cell membrane, which causes cell death. In the action, the molecules of antimicrobial peptides are embedded in the target bacteriological cells and change their conformation, forming structures in some cases resembling channels. Some other molecules of antimicrobial peptides can cover the surface of a bacteriological cell and form a carpet, when they reach a critical mass they act like detergents. In addition, being positively charged molecules of such peptides, penetrating through the membranes of parasitic and bacteriological cells, bind to polyanionic RNA and DNA molecules. Among the benefits of antimicrobial peptides is their high metabolic activity, low probability of occurrence of addictions and side effects. In addition, bacteriological pathogens that previously did not have resistance to any antimicrobial peptide are difficult to develop a strategy to control them. In this connection, these peptides are the most promising moleculessubstitutes for traditional antibiotics. The article discusses the approaches and strategies of therapeutic use, the studies of antimicrobial peptides identified in recent years; The most frequently encountered mechanisms of interaction of antimicrobial peptides and a bacteriological membrane are described, the physicochemical properties of peptide molecules are described; the results of studies on the detection of resistance of some strains of bacteria to antimicrobial peptides and antibiotics in general are summarized.Kh. G. MusinSankt-Peterburg : NIIÈM imeni Pasteraarticleantimicrobial peptidesinnovative drugsimmunopathologydefensinscathelicidinsantibiotics resistanceInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 8, Iss 3, Pp 295-308 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	antimicrobial peptides innovative drugs immunopathology defensins cathelicidins antibiotics resistance Infectious and parasitic diseases RC109-216
spellingShingle	antimicrobial peptides innovative drugs immunopathology defensins cathelicidins antibiotics resistance Infectious and parasitic diseases RC109-216 Kh. G. Musin ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS
description	Antimicrobial peptides are a heterogeneous group of molecules involved in the innate and acquired immune response of various organisms, ranging from prokaryotes to mammals, including humans. They consist of 12–50 amino acid residues; have different physico-chemical and biological properties. The most common feature is their ability to destroy the prokaryotic cell membrane, which causes cell death. In the action, the molecules of antimicrobial peptides are embedded in the target bacteriological cells and change their conformation, forming structures in some cases resembling channels. Some other molecules of antimicrobial peptides can cover the surface of a bacteriological cell and form a carpet, when they reach a critical mass they act like detergents. In addition, being positively charged molecules of such peptides, penetrating through the membranes of parasitic and bacteriological cells, bind to polyanionic RNA and DNA molecules. Among the benefits of antimicrobial peptides is their high metabolic activity, low probability of occurrence of addictions and side effects. In addition, bacteriological pathogens that previously did not have resistance to any antimicrobial peptide are difficult to develop a strategy to control them. In this connection, these peptides are the most promising moleculessubstitutes for traditional antibiotics. The article discusses the approaches and strategies of therapeutic use, the studies of antimicrobial peptides identified in recent years; The most frequently encountered mechanisms of interaction of antimicrobial peptides and a bacteriological membrane are described, the physicochemical properties of peptide molecules are described; the results of studies on the detection of resistance of some strains of bacteria to antimicrobial peptides and antibiotics in general are summarized.
format	article
author	Kh. G. Musin
author_facet	Kh. G. Musin
author_sort	Kh. G. Musin
title	ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS
title_short	ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS
title_full	ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS
title_fullStr	ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS
title_full_unstemmed	ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS
title_sort	antimicrobial peptides — a potential replacement for traditional antibiotics
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/eb6d61543e0248dd91846bb55d8dcbcd
work_keys_str_mv	AT khgmusin antimicrobialpeptidesapotentialreplacementfortraditionalantibiotics
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ANTIMICROBIAL PEPTIDES — A POTENTIAL REPLACEMENT FOR TRADITIONAL ANTIBIOTICS

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