Metabolic requirements of NK cells during the acute response against retroviral infection

Metabolic alterations control the fate and function of immune cells in response to infections, but the function of NK cell metabolism in the context of acute viral infections is unclear. Here the authors show that acute NK cell responses to Friend retrovirus involve increased glycolysis and mitochon...

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Autores principales:	Elisabeth Littwitz-Salomon, Diana Moreira, Joe N. Frost, Chloe Choi, Kevin T. Liou, David K. Ahern, Simon O’Shaughnessy, Bernd Wagner, Christine A. Biron, Hal Drakesmith, Ulf Dittmer, David K. Finlay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb6d712437cd41c090de8bf024bdfc27
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spelling	oai:doaj.org-article:eb6d712437cd41c090de8bf024bdfc272021-12-02T17:19:40ZMetabolic requirements of NK cells during the acute response against retroviral infection10.1038/s41467-021-25715-z2041-1723https://doaj.org/article/eb6d712437cd41c090de8bf024bdfc272021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25715-zhttps://doaj.org/toc/2041-1723Metabolic alterations control the fate and function of immune cells in response to infections, but the function of NK cell metabolism in the context of acute viral infections is unclear. Here the authors show that acute NK cell responses to Friend retrovirus involve increased glycolysis and mitochondrial metabolism and require amino acid transport as well as iron sufficiency.Elisabeth Littwitz-SalomonDiana MoreiraJoe N. FrostChloe ChoiKevin T. LiouDavid K. AhernSimon O’ShaughnessyBernd WagnerChristine A. BironHal DrakesmithUlf DittmerDavid K. FinlayNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elisabeth Littwitz-Salomon Diana Moreira Joe N. Frost Chloe Choi Kevin T. Liou David K. Ahern Simon O’Shaughnessy Bernd Wagner Christine A. Biron Hal Drakesmith Ulf Dittmer David K. Finlay Metabolic requirements of NK cells during the acute response against retroviral infection
description	Metabolic alterations control the fate and function of immune cells in response to infections, but the function of NK cell metabolism in the context of acute viral infections is unclear. Here the authors show that acute NK cell responses to Friend retrovirus involve increased glycolysis and mitochondrial metabolism and require amino acid transport as well as iron sufficiency.
format	article
author	Elisabeth Littwitz-Salomon Diana Moreira Joe N. Frost Chloe Choi Kevin T. Liou David K. Ahern Simon O’Shaughnessy Bernd Wagner Christine A. Biron Hal Drakesmith Ulf Dittmer David K. Finlay
author_facet	Elisabeth Littwitz-Salomon Diana Moreira Joe N. Frost Chloe Choi Kevin T. Liou David K. Ahern Simon O’Shaughnessy Bernd Wagner Christine A. Biron Hal Drakesmith Ulf Dittmer David K. Finlay
author_sort	Elisabeth Littwitz-Salomon
title	Metabolic requirements of NK cells during the acute response against retroviral infection
title_short	Metabolic requirements of NK cells during the acute response against retroviral infection
title_full	Metabolic requirements of NK cells during the acute response against retroviral infection
title_fullStr	Metabolic requirements of NK cells during the acute response against retroviral infection
title_full_unstemmed	Metabolic requirements of NK cells during the acute response against retroviral infection
title_sort	metabolic requirements of nk cells during the acute response against retroviral infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb6d712437cd41c090de8bf024bdfc27
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Metabolic requirements of NK cells during the acute response against retroviral infection

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