Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.
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Nature Portfolio
2018
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oai:doaj.org-article:eb7406c94cd54be79b2b3ac5e46f33e92021-12-02T17:32:48ZVariants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits10.1038/s41467-018-05428-62041-1723https://doaj.org/article/eb7406c94cd54be79b2b3ac5e46f33e92018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05428-6https://doaj.org/toc/2041-1723Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.Thorunn RafnarBjarni GunnarssonOlafur A. StefanssonPatrick SulemAndres IngasonMichael L. FriggeLilja StefansdottirJon K. SigurdssonVinicius TraganteValgerdur SteinthorsdottirUnnur StyrkarsdottirSimon N. StaceyJulius GudmundssonGudny A. ArnadottirAsmundur OddssonFlorian ZinkGisli HalldorssonGardar SveinbjornssonRagnar P. KristjanssonOlafur B. DavidssonAnna SalvarsdottirAsgeir ThoroddsenElisabet A. HelgadottirKatrin KristjansdottirOrri IngthorssonValur GudmundssonReynir T. GeirssonRagnheidur ArnadottirDaniel F. GudbjartssonGisli MassonFolkert W. AsselbergsJon G. JonassonKarl OlafssonUnnur ThorsteinsdottirBjarni V. HalldorssonGudmar ThorleifssonKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
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DOAJ |
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DOAJ |
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Science Q |
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Science Q Thorunn Rafnar Bjarni Gunnarsson Olafur A. Stefansson Patrick Sulem Andres Ingason Michael L. Frigge Lilja Stefansdottir Jon K. Sigurdsson Vinicius Tragante Valgerdur Steinthorsdottir Unnur Styrkarsdottir Simon N. Stacey Julius Gudmundsson Gudny A. Arnadottir Asmundur Oddsson Florian Zink Gisli Halldorsson Gardar Sveinbjornsson Ragnar P. Kristjansson Olafur B. Davidsson Anna Salvarsdottir Asgeir Thoroddsen Elisabet A. Helgadottir Katrin Kristjansdottir Orri Ingthorsson Valur Gudmundsson Reynir T. Geirsson Ragnheidur Arnadottir Daniel F. Gudbjartsson Gisli Masson Folkert W. Asselbergs Jon G. Jonasson Karl Olafsson Unnur Thorsteinsdottir Bjarni V. Halldorsson Gudmar Thorleifsson Kari Stefansson Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| description |
Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth. |
| format |
article |
| author |
Thorunn Rafnar Bjarni Gunnarsson Olafur A. Stefansson Patrick Sulem Andres Ingason Michael L. Frigge Lilja Stefansdottir Jon K. Sigurdsson Vinicius Tragante Valgerdur Steinthorsdottir Unnur Styrkarsdottir Simon N. Stacey Julius Gudmundsson Gudny A. Arnadottir Asmundur Oddsson Florian Zink Gisli Halldorsson Gardar Sveinbjornsson Ragnar P. Kristjansson Olafur B. Davidsson Anna Salvarsdottir Asgeir Thoroddsen Elisabet A. Helgadottir Katrin Kristjansdottir Orri Ingthorsson Valur Gudmundsson Reynir T. Geirsson Ragnheidur Arnadottir Daniel F. Gudbjartsson Gisli Masson Folkert W. Asselbergs Jon G. Jonasson Karl Olafsson Unnur Thorsteinsdottir Bjarni V. Halldorsson Gudmar Thorleifsson Kari Stefansson |
| author_facet |
Thorunn Rafnar Bjarni Gunnarsson Olafur A. Stefansson Patrick Sulem Andres Ingason Michael L. Frigge Lilja Stefansdottir Jon K. Sigurdsson Vinicius Tragante Valgerdur Steinthorsdottir Unnur Styrkarsdottir Simon N. Stacey Julius Gudmundsson Gudny A. Arnadottir Asmundur Oddsson Florian Zink Gisli Halldorsson Gardar Sveinbjornsson Ragnar P. Kristjansson Olafur B. Davidsson Anna Salvarsdottir Asgeir Thoroddsen Elisabet A. Helgadottir Katrin Kristjansdottir Orri Ingthorsson Valur Gudmundsson Reynir T. Geirsson Ragnheidur Arnadottir Daniel F. Gudbjartsson Gisli Masson Folkert W. Asselbergs Jon G. Jonasson Karl Olafsson Unnur Thorsteinsdottir Bjarni V. Halldorsson Gudmar Thorleifsson Kari Stefansson |
| author_sort |
Thorunn Rafnar |
| title |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_short |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_full |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_fullStr |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_full_unstemmed |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_sort |
variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/eb7406c94cd54be79b2b3ac5e46f33e9 |
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