Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report

Abstract Background Inflammatory myofibroblastic tumour is an infrequent mesenchymal neoplasia of unknown aetiology and variable behaviour, ranging from rather benign lesions to locally aggressive and even metastatic disease. Its presence has been described in almost all organs; however, its locatio...

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Autores principales:	Alfonso López de Sa, Alejandro Pascual, Javier Garcia Santos, Ramiro Mendez, Monica Bellon, Mar Ramirez, Fatima Matute, Cristina del Arco, Aránzazu Manzano, Pluvio Coronado, Antonio Casado, Gloria Marquina
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Inflammatory myofibroblastic tumour Soft tissue sarcoma Mesenquimal neoplasia Gynaecologic tumour Cervical tumour Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/eb74c971000e4c69ab8118aa51bdca46
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spelling	oai:doaj.org-article:eb74c971000e4c69ab8118aa51bdca462021-11-21T12:33:40ZInflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report10.1186/s12957-021-02438-51477-7819https://doaj.org/article/eb74c971000e4c69ab8118aa51bdca462021-11-01T00:00:00Zhttps://doi.org/10.1186/s12957-021-02438-5https://doaj.org/toc/1477-7819Abstract Background Inflammatory myofibroblastic tumour is an infrequent mesenchymal neoplasia of unknown aetiology and variable behaviour, ranging from rather benign lesions to locally aggressive and even metastatic disease. Its presence has been described in almost all organs; however, its location in the female genital tract has rarely been reported. Case presentation We present the case of a 47-year-old female, who was studied in our institution for a recent medical history of several weeks of dyspareunia and abdominal pain. She underwent pertinent studies including ultrasonography and CT scan. Under suspicion of degenerated leiomyoma, a total hysterectomy was performed. Unexpectedly, the pathological study of the surgical specimen showed very few tumour cells with focal fusiform morphology surrounded by an abundant inflammatory infiltrate; a thorough immunohistochemistry study lead to myofibroblastic tumour of the cervix diagnosis. A PET-CT scan did not show metastatic disease. The patient did not undergo any adjuvant treatment, and she is currently on surveillance with no evidence of disease relapse. Conclusions Inflammatory myofibroblastic tumour remains a rare entity yet to be fully elucidated. The diagnosis is based on pathological study due to the lack of typical clinical manifestations and typical radiological images. Surgical resection is the most frequent treatment, whereas chemotherapy and radiotherapy are restricted to locally advanced or metastatic disease. Tirosine kinase inhibitor crizotinib has shown promising results especially in tumours harbouring ALK mutation.Alfonso López de SaAlejandro PascualJavier Garcia SantosRamiro MendezMonica BellonMar RamirezFatima MatuteCristina del ArcoAránzazu ManzanoPluvio CoronadoAntonio CasadoGloria MarquinaBMCarticleInflammatory myofibroblastic tumourSoft tissue sarcomaMesenquimal neoplasiaGynaecologic tumourCervical tumourSurgeryRD1-811Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENWorld Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Inflammatory myofibroblastic tumour Soft tissue sarcoma Mesenquimal neoplasia Gynaecologic tumour Cervical tumour Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Inflammatory myofibroblastic tumour Soft tissue sarcoma Mesenquimal neoplasia Gynaecologic tumour Cervical tumour Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alfonso López de Sa Alejandro Pascual Javier Garcia Santos Ramiro Mendez Monica Bellon Mar Ramirez Fatima Matute Cristina del Arco Aránzazu Manzano Pluvio Coronado Antonio Casado Gloria Marquina Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report
description	Abstract Background Inflammatory myofibroblastic tumour is an infrequent mesenchymal neoplasia of unknown aetiology and variable behaviour, ranging from rather benign lesions to locally aggressive and even metastatic disease. Its presence has been described in almost all organs; however, its location in the female genital tract has rarely been reported. Case presentation We present the case of a 47-year-old female, who was studied in our institution for a recent medical history of several weeks of dyspareunia and abdominal pain. She underwent pertinent studies including ultrasonography and CT scan. Under suspicion of degenerated leiomyoma, a total hysterectomy was performed. Unexpectedly, the pathological study of the surgical specimen showed very few tumour cells with focal fusiform morphology surrounded by an abundant inflammatory infiltrate; a thorough immunohistochemistry study lead to myofibroblastic tumour of the cervix diagnosis. A PET-CT scan did not show metastatic disease. The patient did not undergo any adjuvant treatment, and she is currently on surveillance with no evidence of disease relapse. Conclusions Inflammatory myofibroblastic tumour remains a rare entity yet to be fully elucidated. The diagnosis is based on pathological study due to the lack of typical clinical manifestations and typical radiological images. Surgical resection is the most frequent treatment, whereas chemotherapy and radiotherapy are restricted to locally advanced or metastatic disease. Tirosine kinase inhibitor crizotinib has shown promising results especially in tumours harbouring ALK mutation.
format	article
author	Alfonso López de Sa Alejandro Pascual Javier Garcia Santos Ramiro Mendez Monica Bellon Mar Ramirez Fatima Matute Cristina del Arco Aránzazu Manzano Pluvio Coronado Antonio Casado Gloria Marquina
author_facet	Alfonso López de Sa Alejandro Pascual Javier Garcia Santos Ramiro Mendez Monica Bellon Mar Ramirez Fatima Matute Cristina del Arco Aránzazu Manzano Pluvio Coronado Antonio Casado Gloria Marquina
author_sort	Alfonso López de Sa
title	Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report
title_short	Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report
title_full	Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report
title_fullStr	Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report
title_full_unstemmed	Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report
title_sort	inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/eb74c971000e4c69ab8118aa51bdca46
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Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report

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