Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways
Abstract This study aimed to evaluate the acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory and cAMP response element binding (CREB)-related pathways. A total of 120 male Wistar rats were divided into four groups: a control group (C); 2.856 GHz microwave exposure group (S group); 1...
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2021
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oai:doaj.org-article:eb77deee3b4244bc8089de5ca88c43b22021-12-02T17:47:23ZAcute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways10.1038/s41598-021-91622-42045-2322https://doaj.org/article/eb77deee3b4244bc8089de5ca88c43b22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91622-4https://doaj.org/toc/2045-2322Abstract This study aimed to evaluate the acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory and cAMP response element binding (CREB)-related pathways. A total of 120 male Wistar rats were divided into four groups: a control group (C); 2.856 GHz microwave exposure group (S group); 1.5 GHz microwave exposure group (L group); and 2.856 and 1.5 GHz cumulative exposure group (SL group). Decreases in spatial memory abilities, changes in EEG, structural injuries, and the downregulation of phosphorylated-Ak strain transforming (p-AKT), phosphorylated-calcium/calmodulin-dependent protein kinase II (p-CaMKII), phosphorylated extracellular signal regulated kinase (p-ERK) and p-CREB was observed 6 h after microwave exposure. Significant differences in the expression of p-CaMKII were found between the S and L groups. The power amplitudes of the EEG waves (θ, δ), levels of structural injuries and the expression of p-AKT, p-CaMK II, p-CREB, and p-ERK1/2 were significantly different in the S and L groups compared to the SL group. Interaction effects between the 2.856 and 1.5 GHz microwaves were found in the EEG and p-CREB changes. Our findings indicated that 2.856 GHz and 1.5 GHz microwave exposure induced a decline in spatial memory, which might be related to p-AKT, p-CaMK II, p-CREB and p-ERK1/2.Shengzhi TanHui WangXinping XuLi ZhaoJing ZhangJi DongBinwei YaoHaoyu WangYanhui HaoHongmei ZhouYabing GaoRuiyun PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Shengzhi Tan Hui Wang Xinping Xu Li Zhao Jing Zhang Ji Dong Binwei Yao Haoyu Wang Yanhui Hao Hongmei Zhou Yabing Gao Ruiyun Peng Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways |
| description |
Abstract This study aimed to evaluate the acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory and cAMP response element binding (CREB)-related pathways. A total of 120 male Wistar rats were divided into four groups: a control group (C); 2.856 GHz microwave exposure group (S group); 1.5 GHz microwave exposure group (L group); and 2.856 and 1.5 GHz cumulative exposure group (SL group). Decreases in spatial memory abilities, changes in EEG, structural injuries, and the downregulation of phosphorylated-Ak strain transforming (p-AKT), phosphorylated-calcium/calmodulin-dependent protein kinase II (p-CaMKII), phosphorylated extracellular signal regulated kinase (p-ERK) and p-CREB was observed 6 h after microwave exposure. Significant differences in the expression of p-CaMKII were found between the S and L groups. The power amplitudes of the EEG waves (θ, δ), levels of structural injuries and the expression of p-AKT, p-CaMK II, p-CREB, and p-ERK1/2 were significantly different in the S and L groups compared to the SL group. Interaction effects between the 2.856 and 1.5 GHz microwaves were found in the EEG and p-CREB changes. Our findings indicated that 2.856 GHz and 1.5 GHz microwave exposure induced a decline in spatial memory, which might be related to p-AKT, p-CaMK II, p-CREB and p-ERK1/2. |
| format |
article |
| author |
Shengzhi Tan Hui Wang Xinping Xu Li Zhao Jing Zhang Ji Dong Binwei Yao Haoyu Wang Yanhui Hao Hongmei Zhou Yabing Gao Ruiyun Peng |
| author_facet |
Shengzhi Tan Hui Wang Xinping Xu Li Zhao Jing Zhang Ji Dong Binwei Yao Haoyu Wang Yanhui Hao Hongmei Zhou Yabing Gao Ruiyun Peng |
| author_sort |
Shengzhi Tan |
| title |
Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways |
| title_short |
Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways |
| title_full |
Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways |
| title_fullStr |
Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways |
| title_full_unstemmed |
Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways |
| title_sort |
acute effects of 2.856 ghz and 1.5 ghz microwaves on spatial memory abilities and creb-related pathways |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/eb77deee3b4244bc8089de5ca88c43b2 |
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