Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP sign...

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Autores principales:	Seung-Yon Lee, E. Dale Abel, Fanxin Long
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb7aa659cfbd46fab6e60c1ebb511dcd
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spelling	oai:doaj.org-article:eb7aa659cfbd46fab6e60c1ebb511dcd2021-12-02T15:33:35ZGlucose metabolism induced by Bmp signaling is essential for murine skeletal development10.1038/s41467-018-07316-52041-1723https://doaj.org/article/eb7aa659cfbd46fab6e60c1ebb511dcd2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07316-5https://doaj.org/toc/2041-1723It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP signaling.Seung-Yon LeeE. Dale AbelFanxin LongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seung-Yon Lee E. Dale Abel Fanxin Long Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
description	It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP signaling.
format	article
author	Seung-Yon Lee E. Dale Abel Fanxin Long
author_facet	Seung-Yon Lee E. Dale Abel Fanxin Long
author_sort	Seung-Yon Lee
title	Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_short	Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_full	Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_fullStr	Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_full_unstemmed	Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_sort	glucose metabolism induced by bmp signaling is essential for murine skeletal development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eb7aa659cfbd46fab6e60c1ebb511dcd
work_keys_str_mv	AT seungyonlee glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment AT edaleabel glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment AT fanxinlong glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment
_version_	1718387118028357632

Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

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