Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.

Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of...

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Autores principales:	Matthijs G Bossong, J Martijn Jansma, Hendrika H van Hell, Gerry Jager, René S Kahn, Nick F Ramsey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eb7ac0a12e034fe689dc09aa136499aa
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spelling	oai:doaj.org-article:eb7ac0a12e034fe689dc09aa136499aa2021-11-18T09:01:49ZDefault mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.1932-620310.1371/journal.pone.0070074https://doaj.org/article/eb7ac0a12e034fe689dc09aa136499aa2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936144/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of active networks and inhibition of activity in the default mode network. In the present study, we examined the role of the endocannabinoid system in executive function, focusing on both the associated brain network and the default mode network. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted with a placebo-controlled, cross-over design, investigating effects of the endocannabinoid agonist Δ9-tetrahydrocannabinol (THC) on executive function in 20 healthy volunteers, using a continuous performance task with identical pairs. Task performance was impaired after THC administration, reflected in both an increase in false alarms and a reduction in detected targets. This was associated with reduced deactivation in a set of brain regions linked to the default mode network, including posterior cingulate cortex and angular gyrus. Less deactivation was significantly correlated with lower performance after THC. Regions that were activated by the continuous performance task, notably bilateral prefrontal and parietal cortex, did not show effects of THC. These findings suggest an important role for the endocannabinoid system in both default mode modulation and executive function. This may be relevant for psychiatric disorders associated with executive function deficits, such as schizophrenia and ADHD.Matthijs G BossongJ Martijn JansmaHendrika H van HellGerry JagerRené S KahnNick F RamseyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e70074 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthijs G Bossong J Martijn Jansma Hendrika H van Hell Gerry Jager René S Kahn Nick F Ramsey Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.
description	Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of active networks and inhibition of activity in the default mode network. In the present study, we examined the role of the endocannabinoid system in executive function, focusing on both the associated brain network and the default mode network. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted with a placebo-controlled, cross-over design, investigating effects of the endocannabinoid agonist Δ9-tetrahydrocannabinol (THC) on executive function in 20 healthy volunteers, using a continuous performance task with identical pairs. Task performance was impaired after THC administration, reflected in both an increase in false alarms and a reduction in detected targets. This was associated with reduced deactivation in a set of brain regions linked to the default mode network, including posterior cingulate cortex and angular gyrus. Less deactivation was significantly correlated with lower performance after THC. Regions that were activated by the continuous performance task, notably bilateral prefrontal and parietal cortex, did not show effects of THC. These findings suggest an important role for the endocannabinoid system in both default mode modulation and executive function. This may be relevant for psychiatric disorders associated with executive function deficits, such as schizophrenia and ADHD.
format	article
author	Matthijs G Bossong J Martijn Jansma Hendrika H van Hell Gerry Jager René S Kahn Nick F Ramsey
author_facet	Matthijs G Bossong J Martijn Jansma Hendrika H van Hell Gerry Jager René S Kahn Nick F Ramsey
author_sort	Matthijs G Bossong
title	Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.
title_short	Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.
title_full	Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.
title_fullStr	Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.
title_full_unstemmed	Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.
title_sort	default mode network in the effects of δ9-tetrahydrocannabinol (thc) on human executive function.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/eb7ac0a12e034fe689dc09aa136499aa
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Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.

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