A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.

Guardado en:
Detalles Bibliográficos
Autores principales: Sherry Y. Wu, Rajesha Rupaimoole, Fangrong Shen, Sunila Pradeep, Chad V. Pecot, Cristina Ivan, Archana S. Nagaraja, Kshipra M. Gharpure, Elizabeth Pham, Hiroto Hatakeyama, Michael H. McGuire, Monika Haemmerle, Viviana Vidal-Anaya, Courtney Olsen, Cristian Rodriguez-Aguayo, Justyna Filant, Ehsan A. Ehsanipour, Shelley M. Herbrich, Sourindra N. Maiti, Li Huang, Ji Hoon Kim, Xinna Zhang, Hee-Dong Han, Guillermo N. Armaiz-Pena, Elena G. Seviour, Sue Tucker, Min Zhang, Da Yang, Laurence J. N. Cooper, Rouba Ali-Fehmi, Menashe Bar-Eli, Ju-Seog Lee, Prahlad T. Ram, Keith A. Baggerly, Gabriel Lopez-Berestein, Mien-Chie Hung, Anil K. Sood
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/eb7d16e04f0748669c65e11456597cc9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:eb7d16e04f0748669c65e11456597cc9
record_format dspace
spelling oai:doaj.org-article:eb7d16e04f0748669c65e11456597cc92021-12-02T17:32:49ZA miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer10.1038/ncomms111692041-1723https://doaj.org/article/eb7d16e04f0748669c65e11456597cc92016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11169https://doaj.org/toc/2041-1723The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.Sherry Y. WuRajesha RupaimooleFangrong ShenSunila PradeepChad V. PecotCristina IvanArchana S. NagarajaKshipra M. GharpureElizabeth PhamHiroto HatakeyamaMichael H. McGuireMonika HaemmerleViviana Vidal-AnayaCourtney OlsenCristian Rodriguez-AguayoJustyna FilantEhsan A. EhsanipourShelley M. HerbrichSourindra N. MaitiLi HuangJi Hoon KimXinna ZhangHee-Dong HanGuillermo N. Armaiz-PenaElena G. SeviourSue TuckerMin ZhangDa YangLaurence J. N. CooperRouba Ali-FehmiMenashe Bar-EliJu-Seog LeePrahlad T. RamKeith A. BaggerlyGabriel Lopez-BeresteinMien-Chie HungAnil K. SoodNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sherry Y. Wu
Rajesha Rupaimoole
Fangrong Shen
Sunila Pradeep
Chad V. Pecot
Cristina Ivan
Archana S. Nagaraja
Kshipra M. Gharpure
Elizabeth Pham
Hiroto Hatakeyama
Michael H. McGuire
Monika Haemmerle
Viviana Vidal-Anaya
Courtney Olsen
Cristian Rodriguez-Aguayo
Justyna Filant
Ehsan A. Ehsanipour
Shelley M. Herbrich
Sourindra N. Maiti
Li Huang
Ji Hoon Kim
Xinna Zhang
Hee-Dong Han
Guillermo N. Armaiz-Pena
Elena G. Seviour
Sue Tucker
Min Zhang
Da Yang
Laurence J. N. Cooper
Rouba Ali-Fehmi
Menashe Bar-Eli
Ju-Seog Lee
Prahlad T. Ram
Keith A. Baggerly
Gabriel Lopez-Berestein
Mien-Chie Hung
Anil K. Sood
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
description The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.
format article
author Sherry Y. Wu
Rajesha Rupaimoole
Fangrong Shen
Sunila Pradeep
Chad V. Pecot
Cristina Ivan
Archana S. Nagaraja
Kshipra M. Gharpure
Elizabeth Pham
Hiroto Hatakeyama
Michael H. McGuire
Monika Haemmerle
Viviana Vidal-Anaya
Courtney Olsen
Cristian Rodriguez-Aguayo
Justyna Filant
Ehsan A. Ehsanipour
Shelley M. Herbrich
Sourindra N. Maiti
Li Huang
Ji Hoon Kim
Xinna Zhang
Hee-Dong Han
Guillermo N. Armaiz-Pena
Elena G. Seviour
Sue Tucker
Min Zhang
Da Yang
Laurence J. N. Cooper
Rouba Ali-Fehmi
Menashe Bar-Eli
Ju-Seog Lee
Prahlad T. Ram
Keith A. Baggerly
Gabriel Lopez-Berestein
Mien-Chie Hung
Anil K. Sood
author_facet Sherry Y. Wu
Rajesha Rupaimoole
Fangrong Shen
Sunila Pradeep
Chad V. Pecot
Cristina Ivan
Archana S. Nagaraja
Kshipra M. Gharpure
Elizabeth Pham
Hiroto Hatakeyama
Michael H. McGuire
Monika Haemmerle
Viviana Vidal-Anaya
Courtney Olsen
Cristian Rodriguez-Aguayo
Justyna Filant
Ehsan A. Ehsanipour
Shelley M. Herbrich
Sourindra N. Maiti
Li Huang
Ji Hoon Kim
Xinna Zhang
Hee-Dong Han
Guillermo N. Armaiz-Pena
Elena G. Seviour
Sue Tucker
Min Zhang
Da Yang
Laurence J. N. Cooper
Rouba Ali-Fehmi
Menashe Bar-Eli
Ju-Seog Lee
Prahlad T. Ram
Keith A. Baggerly
Gabriel Lopez-Berestein
Mien-Chie Hung
Anil K. Sood
author_sort Sherry Y. Wu
title A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
title_short A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
title_full A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
title_fullStr A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
title_full_unstemmed A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
title_sort mir-192-egr1-hoxb9 regulatory network controls the angiogenic switch in cancer
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/eb7d16e04f0748669c65e11456597cc9
work_keys_str_mv AT sherryywu amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT rajesharupaimoole amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT fangrongshen amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT sunilapradeep amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT chadvpecot amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT cristinaivan amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT archanasnagaraja amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT kshipramgharpure amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT elizabethpham amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT hirotohatakeyama amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT michaelhmcguire amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT monikahaemmerle amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT vivianavidalanaya amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT courtneyolsen amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT cristianrodriguezaguayo amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT justynafilant amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT ehsanaehsanipour amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT shelleymherbrich amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT sourindranmaiti amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT lihuang amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT jihoonkim amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT xinnazhang amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT heedonghan amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT guillermonarmaizpena amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT elenagseviour amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT suetucker amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT minzhang amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT dayang amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT laurencejncooper amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT roubaalifehmi amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT menashebareli amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT juseoglee amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT prahladtram amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT keithabaggerly amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT gabriellopezberestein amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT mienchiehung amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT anilksood amir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT sherryywu mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT rajesharupaimoole mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT fangrongshen mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT sunilapradeep mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT chadvpecot mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT cristinaivan mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT archanasnagaraja mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT kshipramgharpure mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT elizabethpham mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT hirotohatakeyama mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT michaelhmcguire mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT monikahaemmerle mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT vivianavidalanaya mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT courtneyolsen mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT cristianrodriguezaguayo mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT justynafilant mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT ehsanaehsanipour mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT shelleymherbrich mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT sourindranmaiti mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT lihuang mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT jihoonkim mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT xinnazhang mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT heedonghan mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT guillermonarmaizpena mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT elenagseviour mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT suetucker mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT minzhang mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT dayang mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT laurencejncooper mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT roubaalifehmi mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT menashebareli mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT juseoglee mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT prahladtram mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT keithabaggerly mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT gabriellopezberestein mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT mienchiehung mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
AT anilksood mir192egr1hoxb9regulatorynetworkcontrolstheangiogenicswitchincancer
_version_ 1718380219630354432

Ejemplares similares