Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients

Abstract Neuroimaging studies have revealed how intrinsic dysconnectivity among cortical regions of the mentalizing network (MENT) and the mirror neuron system (MNS) could explain the theory of mind (ToM) deficit in schizophrenia patients. However, despite the concurrent involvement of the cerebellu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Soo Hwan Park, Taekwan Kim, Minji Ha, Sun-Young Moon, Silvia Kyungjin Lho, Minah Kim, Jun Soo Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/eb8191c5034c4b799456f6c0e4f783b7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb8191c5034c4b799456f6c0e4f783b7
record_format	dspace
spelling	oai:doaj.org-article:eb8191c5034c4b799456f6c0e4f783b72021-12-05T12:10:26ZIntrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients10.1038/s41537-021-00193-w2334-265Xhttps://doaj.org/article/eb8191c5034c4b799456f6c0e4f783b72021-12-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00193-whttps://doaj.org/toc/2334-265XAbstract Neuroimaging studies have revealed how intrinsic dysconnectivity among cortical regions of the mentalizing network (MENT) and the mirror neuron system (MNS) could explain the theory of mind (ToM) deficit in schizophrenia patients. However, despite the concurrent involvement of the cerebellum with the cortex in social cognition, the dysfunction in intrinsic interplay between the cerebellar nodes of MENT/MNS and the cortex in schizophrenia patients remains unknown. Thus, we aimed to investigate whether resting-state cerebello–cortical dysconnectivity exists in first-episode psychosis (FEP) patients in relationship with their ToM deficit. A total of 37 FEP patients and 80 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. Using a priori-defined cerebellar seeds that functionally connect to the MENT (right crus II) and MNS (right crus I), we compared cerebello–cortical functional connectivities (FCs) in FEP patients and HCs. Correlations between cerebello–parietal connectivities and ToM performance were investigated in FEP patients. FEP patients showed hyperconnectivity between the right crus II and anterior cingulate gyrus and between the right crus I and supplementary motor area, bilateral postcentral gyrus, and right central/parietal operculum (CO/PO). Hypoconnectivity was found between the right crus II and left supramarginal gyrus (SMG) in FEP patients. FCs between the right crus II and left SMG and between the right crus I and right CO/PO were significantly correlated with ToM scores in FEP patients. In accordance with the “cognitive dysmetria” hypothesis, our results highlight the importance of cerbello-cortical dysconnectivities in understanding social cognitive deficits in schizophrenia patients.Soo Hwan ParkTaekwan KimMinji HaSun-Young MoonSilvia Kyungjin LhoMinah KimJun Soo KwonNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Soo Hwan Park Taekwan Kim Minji Ha Sun-Young Moon Silvia Kyungjin Lho Minah Kim Jun Soo Kwon Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients
description	Abstract Neuroimaging studies have revealed how intrinsic dysconnectivity among cortical regions of the mentalizing network (MENT) and the mirror neuron system (MNS) could explain the theory of mind (ToM) deficit in schizophrenia patients. However, despite the concurrent involvement of the cerebellum with the cortex in social cognition, the dysfunction in intrinsic interplay between the cerebellar nodes of MENT/MNS and the cortex in schizophrenia patients remains unknown. Thus, we aimed to investigate whether resting-state cerebello–cortical dysconnectivity exists in first-episode psychosis (FEP) patients in relationship with their ToM deficit. A total of 37 FEP patients and 80 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. Using a priori-defined cerebellar seeds that functionally connect to the MENT (right crus II) and MNS (right crus I), we compared cerebello–cortical functional connectivities (FCs) in FEP patients and HCs. Correlations between cerebello–parietal connectivities and ToM performance were investigated in FEP patients. FEP patients showed hyperconnectivity between the right crus II and anterior cingulate gyrus and between the right crus I and supplementary motor area, bilateral postcentral gyrus, and right central/parietal operculum (CO/PO). Hypoconnectivity was found between the right crus II and left supramarginal gyrus (SMG) in FEP patients. FCs between the right crus II and left SMG and between the right crus I and right CO/PO were significantly correlated with ToM scores in FEP patients. In accordance with the “cognitive dysmetria” hypothesis, our results highlight the importance of cerbello-cortical dysconnectivities in understanding social cognitive deficits in schizophrenia patients.
format	article
author	Soo Hwan Park Taekwan Kim Minji Ha Sun-Young Moon Silvia Kyungjin Lho Minah Kim Jun Soo Kwon
author_facet	Soo Hwan Park Taekwan Kim Minji Ha Sun-Young Moon Silvia Kyungjin Lho Minah Kim Jun Soo Kwon
author_sort	Soo Hwan Park
title	Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients
title_short	Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients
title_full	Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients
title_fullStr	Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients
title_full_unstemmed	Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients
title_sort	intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eb8191c5034c4b799456f6c0e4f783b7
work_keys_str_mv	AT soohwanpark intrinsiccerebellarfunctionalconnectivityofsocialcognitionandtheoryofmindinfirstepisodepsychosispatients AT taekwankim intrinsiccerebellarfunctionalconnectivityofsocialcognitionandtheoryofmindinfirstepisodepsychosispatients AT minjiha intrinsiccerebellarfunctionalconnectivityofsocialcognitionandtheoryofmindinfirstepisodepsychosispatients AT sunyoungmoon intrinsiccerebellarfunctionalconnectivityofsocialcognitionandtheoryofmindinfirstepisodepsychosispatients AT silviakyungjinlho intrinsiccerebellarfunctionalconnectivityofsocialcognitionandtheoryofmindinfirstepisodepsychosispatients AT minahkim intrinsiccerebellarfunctionalconnectivityofsocialcognitionandtheoryofmindinfirstepisodepsychosispatients AT junsookwon intrinsiccerebellarfunctionalconnectivityofsocialcognitionandtheoryofmindinfirstepisodepsychosispatients
_version_	1718372227572826112

Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients

Ejemplares similares