Characteristics of brain functional and structural connectivity in alexithymic students

Yantong Fang,1 Mei Li,2 Minjun Mei,2 Xiaofei Sun,2 Dai Han,1,3,4 1Children and Adolescents Mental Health Joint Clinic, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 2Mental Health Education and Counseling Center, Hangzhou Normal Uni...

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Autores principales:	Fang Y, Li M, Mei M, Sun X, Han D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	rsfMRI DTI functional connectivity structural connectivity alexithymia. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/eb826a52a4fc416194e61aa0a2b8fc12
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spelling	oai:doaj.org-article:eb826a52a4fc416194e61aa0a2b8fc122021-12-02T05:57:02ZCharacteristics of brain functional and structural connectivity in alexithymic students1178-2021https://doaj.org/article/eb826a52a4fc416194e61aa0a2b8fc122018-10-01T00:00:00Zhttps://www.dovepress.com/characteristics-of-brain-functional-and-structural-connectivity-in-ale-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yantong Fang,1 Mei Li,2 Minjun Mei,2 Xiaofei Sun,2 Dai Han,1,3,4 1Children and Adolescents Mental Health Joint Clinic, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 2Mental Health Education and Counseling Center, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 3Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 4Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, People’s Republic of China Background: Alexithymia is a multifaceted personality trait and a risk factor for several mental and physical diseases. Methods: In this study, 21 alexithymic students and 21 nonalexithymic students were recruited from the local university and assigned to the alexithymic group and the control group, respectively. Then, the functional connectivity and the structural connectivity among the brain regions of the students were investigated using resting-state functional magnetic resonance imaging (rsfMRI), function connection (FC) analysis, and diffusion tensor imaging (DTI). Results: The rsfMRI results revealed 14 brain regions showing significant differences in the amplitude of low-frequency fluctuations between the two groups. Comparative analysis of the FC and DTI data in these brain regions between the two groups identified altered levels of functional and structural connectivity between the following four pairs of regions in the alexithymic subjects: the right inferior temporal gyrus and the central posterior gyrus, the left temporal gyrus and the insula, and the bilateral superior frontal gyrus and the anterior cingulate gyrus. Conclusion: Compared with single MRI analysis, the multiple MRI analysis identified more precisely the brain regions that could play a key role in the development of alexithymia. Keywords: rsfMRI, DTI, functional connectivity, structural connectivity, alexithymiaFang YLi MMei MSun XHan DDove Medical PressarticlersfMRIDTIfunctional connectivitystructural connectivityalexithymia.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2609-2615 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	rsfMRI DTI functional connectivity structural connectivity alexithymia. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	rsfMRI DTI functional connectivity structural connectivity alexithymia. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Fang Y Li M Mei M Sun X Han D Characteristics of brain functional and structural connectivity in alexithymic students
description	Yantong Fang,1 Mei Li,2 Minjun Mei,2 Xiaofei Sun,2 Dai Han,1,3,4 1Children and Adolescents Mental Health Joint Clinic, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 2Mental Health Education and Counseling Center, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 3Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 4Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, People’s Republic of China Background: Alexithymia is a multifaceted personality trait and a risk factor for several mental and physical diseases. Methods: In this study, 21 alexithymic students and 21 nonalexithymic students were recruited from the local university and assigned to the alexithymic group and the control group, respectively. Then, the functional connectivity and the structural connectivity among the brain regions of the students were investigated using resting-state functional magnetic resonance imaging (rsfMRI), function connection (FC) analysis, and diffusion tensor imaging (DTI). Results: The rsfMRI results revealed 14 brain regions showing significant differences in the amplitude of low-frequency fluctuations between the two groups. Comparative analysis of the FC and DTI data in these brain regions between the two groups identified altered levels of functional and structural connectivity between the following four pairs of regions in the alexithymic subjects: the right inferior temporal gyrus and the central posterior gyrus, the left temporal gyrus and the insula, and the bilateral superior frontal gyrus and the anterior cingulate gyrus. Conclusion: Compared with single MRI analysis, the multiple MRI analysis identified more precisely the brain regions that could play a key role in the development of alexithymia. Keywords: rsfMRI, DTI, functional connectivity, structural connectivity, alexithymia
format	article
author	Fang Y Li M Mei M Sun X Han D
author_facet	Fang Y Li M Mei M Sun X Han D
author_sort	Fang Y
title	Characteristics of brain functional and structural connectivity in alexithymic students
title_short	Characteristics of brain functional and structural connectivity in alexithymic students
title_full	Characteristics of brain functional and structural connectivity in alexithymic students
title_fullStr	Characteristics of brain functional and structural connectivity in alexithymic students
title_full_unstemmed	Characteristics of brain functional and structural connectivity in alexithymic students
title_sort	characteristics of brain functional and structural connectivity in alexithymic students
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/eb826a52a4fc416194e61aa0a2b8fc12
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_version_	1718400145047945216

Characteristics of brain functional and structural connectivity in alexithymic students

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