Clinical and biological markers for predicting ARDS and outcome in septic patients
Abstract Sepsis is a common cause of acute respiratory distress syndrome (ARDS) associated with a high mortality. A panel of biomarkers (BMs) to identify septic patients at risk for developing ARDS, or at high risk of death, would be of interest for selecting patients for therapeutic trials, which c...
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Nature Portfolio
2021
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oai:doaj.org-article:eb84a8637b1a44debce07e112513328f2021-11-28T12:15:51ZClinical and biological markers for predicting ARDS and outcome in septic patients10.1038/s41598-021-02100-w2045-2322https://doaj.org/article/eb84a8637b1a44debce07e112513328f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02100-whttps://doaj.org/toc/2045-2322Abstract Sepsis is a common cause of acute respiratory distress syndrome (ARDS) associated with a high mortality. A panel of biomarkers (BMs) to identify septic patients at risk for developing ARDS, or at high risk of death, would be of interest for selecting patients for therapeutic trials, which could improve ARDS diagnosis and treatment, and survival chances in sepsis and ARDS. We measured nine protein BMs by ELISA in serum from 232 adult septic patients at diagnosis (152 required invasive mechanical ventilation and 72 had ARDS). A panel including the BMs RAGE, CXCL16 and Ang-2, plus PaO2/FiO2, was good in predicting ARDS (area under the curve = 0.88 in total septic patients). Best performing panels for ICU death are related to the presence of ARDS, need for invasive mechanical ventilation, and pulmonary/extrapulmonary origin of sepsis. In all cases, the use of BMs improved the prediction by clinical markers. Our study confirms the relevance of RAGE, Ang-2, IL-1RA and SP-D, and is novel supporting the inclusion of CXCL16, in BMs panels for predicting ARDS diagnosis and ARDS and sepsis outcome.Jesús VillarRubén Herrán-MongeElena González-HiguerasMiryam Prieto-GonzálezAlfonso AmbrósAurelio Rodríguez-PérezArturo Muriel-BombínRosario SolanoCristina Cuenca-RubioAnxela VidalCarlos FloresJesús M. González-MartínM. Isabel García-LaordenGenetics of Sepsis (GEN-SEP) NetworkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Jesús Villar Rubén Herrán-Monge Elena González-Higueras Miryam Prieto-González Alfonso Ambrós Aurelio Rodríguez-Pérez Arturo Muriel-Bombín Rosario Solano Cristina Cuenca-Rubio Anxela Vidal Carlos Flores Jesús M. González-Martín M. Isabel García-Laorden Genetics of Sepsis (GEN-SEP) Network Clinical and biological markers for predicting ARDS and outcome in septic patients |
| description |
Abstract Sepsis is a common cause of acute respiratory distress syndrome (ARDS) associated with a high mortality. A panel of biomarkers (BMs) to identify septic patients at risk for developing ARDS, or at high risk of death, would be of interest for selecting patients for therapeutic trials, which could improve ARDS diagnosis and treatment, and survival chances in sepsis and ARDS. We measured nine protein BMs by ELISA in serum from 232 adult septic patients at diagnosis (152 required invasive mechanical ventilation and 72 had ARDS). A panel including the BMs RAGE, CXCL16 and Ang-2, plus PaO2/FiO2, was good in predicting ARDS (area under the curve = 0.88 in total septic patients). Best performing panels for ICU death are related to the presence of ARDS, need for invasive mechanical ventilation, and pulmonary/extrapulmonary origin of sepsis. In all cases, the use of BMs improved the prediction by clinical markers. Our study confirms the relevance of RAGE, Ang-2, IL-1RA and SP-D, and is novel supporting the inclusion of CXCL16, in BMs panels for predicting ARDS diagnosis and ARDS and sepsis outcome. |
| format |
article |
| author |
Jesús Villar Rubén Herrán-Monge Elena González-Higueras Miryam Prieto-González Alfonso Ambrós Aurelio Rodríguez-Pérez Arturo Muriel-Bombín Rosario Solano Cristina Cuenca-Rubio Anxela Vidal Carlos Flores Jesús M. González-Martín M. Isabel García-Laorden Genetics of Sepsis (GEN-SEP) Network |
| author_facet |
Jesús Villar Rubén Herrán-Monge Elena González-Higueras Miryam Prieto-González Alfonso Ambrós Aurelio Rodríguez-Pérez Arturo Muriel-Bombín Rosario Solano Cristina Cuenca-Rubio Anxela Vidal Carlos Flores Jesús M. González-Martín M. Isabel García-Laorden Genetics of Sepsis (GEN-SEP) Network |
| author_sort |
Jesús Villar |
| title |
Clinical and biological markers for predicting ARDS and outcome in septic patients |
| title_short |
Clinical and biological markers for predicting ARDS and outcome in septic patients |
| title_full |
Clinical and biological markers for predicting ARDS and outcome in septic patients |
| title_fullStr |
Clinical and biological markers for predicting ARDS and outcome in septic patients |
| title_full_unstemmed |
Clinical and biological markers for predicting ARDS and outcome in septic patients |
| title_sort |
clinical and biological markers for predicting ards and outcome in septic patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/eb84a8637b1a44debce07e112513328f |
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