Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia
Abstract Although gestational hypertension (GH) is a well-known disorder, gestational proteinuria (GP) has been far less emphasized. According to international criteria, hypertensive disorders of pregnancy include GH but not GP. Previous studies have not revealed the predictors of progression from G...
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Nature Portfolio
2021
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oai:doaj.org-article:eb85995fe00042db9facb8acd5338a1c2021-12-02T17:40:47ZEarlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia10.1038/s41598-021-92189-w2045-2322https://doaj.org/article/eb85995fe00042db9facb8acd5338a1c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92189-whttps://doaj.org/toc/2045-2322Abstract Although gestational hypertension (GH) is a well-known disorder, gestational proteinuria (GP) has been far less emphasized. According to international criteria, hypertensive disorders of pregnancy include GH but not GP. Previous studies have not revealed the predictors of progression from GP to preeclampsia or those of progression from GH to preeclampsia. We aimed to determine both sets of predictors. A retrospective cohort study was conducted with singleton pregnant women who delivered at 22 gestational weeks or later. Preeclampsia was divided into three types: new onset of hypertension/proteinuria at 20 gestational weeks or later and additional new onset of other symptoms at < 7 days or at ≥ 7 days later. Of 94 women with preeclampsia, 20 exhibited proteinuria before preeclampsia, 14 experienced hypertension before preeclampsia, and 60 exhibited simultaneous new onset of both hypertension and proteinuria before preeclampsia; the outcomes of all types were similar. Of 34 women with presumptive GP, 58.8% developed preeclampsia; this proportion was significantly higher than that of 89 women with presumptive GH who developed preeclampsia (15.7%). According to multivariate logistic regression models, earlier onset of hypertension/proteinuria (before or at 34.7/33.9 gestational weeks) was a predicator for progression from presumptive GH/GP to preeclampsia (odds ratios: 1.21/1.21, P value: 0.0044/0.0477, respectively).Mamoru MorikawaMichinori MayamaKiwamu NoshiroYoshihiro SaitoKinuko Nakagawa-AkabaneTakeshi UmazumeKentaro ChibaSatoshi KawaguchiHidemichi WatariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Mamoru Morikawa Michinori Mayama Kiwamu Noshiro Yoshihiro Saito Kinuko Nakagawa-Akabane Takeshi Umazume Kentaro Chiba Satoshi Kawaguchi Hidemichi Watari Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia |
| description |
Abstract Although gestational hypertension (GH) is a well-known disorder, gestational proteinuria (GP) has been far less emphasized. According to international criteria, hypertensive disorders of pregnancy include GH but not GP. Previous studies have not revealed the predictors of progression from GP to preeclampsia or those of progression from GH to preeclampsia. We aimed to determine both sets of predictors. A retrospective cohort study was conducted with singleton pregnant women who delivered at 22 gestational weeks or later. Preeclampsia was divided into three types: new onset of hypertension/proteinuria at 20 gestational weeks or later and additional new onset of other symptoms at < 7 days or at ≥ 7 days later. Of 94 women with preeclampsia, 20 exhibited proteinuria before preeclampsia, 14 experienced hypertension before preeclampsia, and 60 exhibited simultaneous new onset of both hypertension and proteinuria before preeclampsia; the outcomes of all types were similar. Of 34 women with presumptive GP, 58.8% developed preeclampsia; this proportion was significantly higher than that of 89 women with presumptive GH who developed preeclampsia (15.7%). According to multivariate logistic regression models, earlier onset of hypertension/proteinuria (before or at 34.7/33.9 gestational weeks) was a predicator for progression from presumptive GH/GP to preeclampsia (odds ratios: 1.21/1.21, P value: 0.0044/0.0477, respectively). |
| format |
article |
| author |
Mamoru Morikawa Michinori Mayama Kiwamu Noshiro Yoshihiro Saito Kinuko Nakagawa-Akabane Takeshi Umazume Kentaro Chiba Satoshi Kawaguchi Hidemichi Watari |
| author_facet |
Mamoru Morikawa Michinori Mayama Kiwamu Noshiro Yoshihiro Saito Kinuko Nakagawa-Akabane Takeshi Umazume Kentaro Chiba Satoshi Kawaguchi Hidemichi Watari |
| author_sort |
Mamoru Morikawa |
| title |
Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia |
| title_short |
Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia |
| title_full |
Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia |
| title_fullStr |
Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia |
| title_full_unstemmed |
Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia |
| title_sort |
earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/eb85995fe00042db9facb8acd5338a1c |
| work_keys_str_mv |
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