Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?

Abstract The recent emergence of severe acute respiratory syndrome-Corona Virus 2 (SARS-CoV-2) in late 2019 and its spread worldwide caused an acute pandemic of Coronavirus disease 19 (COVID-19). Since then, COVID-19 has been under intense scrutiny as its outbreak led to significant changes in healt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kavya Srinivasan, Ashutosh Kumar Pandey, Ashlena Livingston, Sundararajan Venkatesh
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	COVID-19 SARS-CoV-2 Mitochondria ACE-2 receptor Cytokine storm Inflammation Medicine R
Acceso en línea:	https://doaj.org/article/eb8ae861dd8748d38f8c1dbfddd6fde6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb8ae861dd8748d38f8c1dbfddd6fde6
record_format	dspace
spelling	oai:doaj.org-article:eb8ae861dd8748d38f8c1dbfddd6fde62021-11-28T12:04:57ZRoles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?10.1186/s43556-021-00060-12662-8651https://doaj.org/article/eb8ae861dd8748d38f8c1dbfddd6fde62021-11-01T00:00:00Zhttps://doi.org/10.1186/s43556-021-00060-1https://doaj.org/toc/2662-8651Abstract The recent emergence of severe acute respiratory syndrome-Corona Virus 2 (SARS-CoV-2) in late 2019 and its spread worldwide caused an acute pandemic of Coronavirus disease 19 (COVID-19). Since then, COVID-19 has been under intense scrutiny as its outbreak led to significant changes in healthcare, social activities, and economic settings worldwide. Although angiotensin-converting enzyme-2 (ACE-2) receptor is shown to be the primary port of SARS-CoV-2 entry in cells, the mechanisms behind the establishment and pathologies of COVID-19 are poorly understood. As recent studies have shown that host mitochondria play an essential role in virus-mediated innate immune response, pathologies, and infection, in this review, we will discuss in detail the entry and progression of SARS-CoV-2 and how mitochondria could play roles in COVID-19 disease. We will also review the potential interactions between SARS-CoV-2 and mitochondria and discuss possible treatments, including whether mitochondria as a potential therapeutic target in COVID-19. Understanding SARS-CoV-2 and mitochondrial interactions mediated virus establishment, inflammation, and other consequences may provide a unique mechanism and conceptual advancement in finding a novel treatment for COVID-19.Kavya SrinivasanAshutosh Kumar PandeyAshlena LivingstonSundararajan VenkateshSpringerarticleCOVID-19SARS-CoV-2MitochondriaACE-2 receptorCytokine stormInflammationMedicineRENMolecular Biomedicine, Vol 2, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 Mitochondria ACE-2 receptor Cytokine storm Inflammation Medicine R
spellingShingle	COVID-19 SARS-CoV-2 Mitochondria ACE-2 receptor Cytokine storm Inflammation Medicine R Kavya Srinivasan Ashutosh Kumar Pandey Ashlena Livingston Sundararajan Venkatesh Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
description	Abstract The recent emergence of severe acute respiratory syndrome-Corona Virus 2 (SARS-CoV-2) in late 2019 and its spread worldwide caused an acute pandemic of Coronavirus disease 19 (COVID-19). Since then, COVID-19 has been under intense scrutiny as its outbreak led to significant changes in healthcare, social activities, and economic settings worldwide. Although angiotensin-converting enzyme-2 (ACE-2) receptor is shown to be the primary port of SARS-CoV-2 entry in cells, the mechanisms behind the establishment and pathologies of COVID-19 are poorly understood. As recent studies have shown that host mitochondria play an essential role in virus-mediated innate immune response, pathologies, and infection, in this review, we will discuss in detail the entry and progression of SARS-CoV-2 and how mitochondria could play roles in COVID-19 disease. We will also review the potential interactions between SARS-CoV-2 and mitochondria and discuss possible treatments, including whether mitochondria as a potential therapeutic target in COVID-19. Understanding SARS-CoV-2 and mitochondrial interactions mediated virus establishment, inflammation, and other consequences may provide a unique mechanism and conceptual advancement in finding a novel treatment for COVID-19.
format	article
author	Kavya Srinivasan Ashutosh Kumar Pandey Ashlena Livingston Sundararajan Venkatesh
author_facet	Kavya Srinivasan Ashutosh Kumar Pandey Ashlena Livingston Sundararajan Venkatesh
author_sort	Kavya Srinivasan
title	Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
title_short	Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
title_full	Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
title_fullStr	Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
title_full_unstemmed	Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
title_sort	roles of host mitochondria in the development of covid-19 pathology: could mitochondria be a potential therapeutic target?
publisher	Springer
publishDate	2021
url	https://doaj.org/article/eb8ae861dd8748d38f8c1dbfddd6fde6
work_keys_str_mv	AT kavyasrinivasan rolesofhostmitochondriainthedevelopmentofcovid19pathologycouldmitochondriabeapotentialtherapeutictarget AT ashutoshkumarpandey rolesofhostmitochondriainthedevelopmentofcovid19pathologycouldmitochondriabeapotentialtherapeutictarget AT ashlenalivingston rolesofhostmitochondriainthedevelopmentofcovid19pathologycouldmitochondriabeapotentialtherapeutictarget AT sundararajanvenkatesh rolesofhostmitochondriainthedevelopmentofcovid19pathologycouldmitochondriabeapotentialtherapeutictarget
_version_	1718408232248016896

Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?

Ejemplares similares