Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages

Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this r...

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Autores principales:	David A. Rollins, Joubert B. Kharlyngdoh, Maddalena Coppo, Bowranigan Tharmalingam, Sanda Mimouna, Ziyi Guo, Maria A. Sacta, Miles A. Pufall, Robert P. Fisher, Xiaoyu Hu, Yurii Chinenov, Inez Rogatsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb8bc334966c4fed854765322ec786b6
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spelling	oai:doaj.org-article:eb8bc334966c4fed854765322ec786b62021-12-02T15:38:49ZGlucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages10.1038/s41467-017-01569-22041-1723https://doaj.org/article/eb8bc334966c4fed854765322ec786b62017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01569-2https://doaj.org/toc/2041-1723Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this response in macrophage.David A. RollinsJoubert B. KharlyngdohMaddalena CoppoBowranigan TharmalingamSanda MimounaZiyi GuoMaria A. SactaMiles A. PufallRobert P. FisherXiaoyu HuYurii ChinenovInez RogatskyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David A. Rollins Joubert B. Kharlyngdoh Maddalena Coppo Bowranigan Tharmalingam Sanda Mimouna Ziyi Guo Maria A. Sacta Miles A. Pufall Robert P. Fisher Xiaoyu Hu Yurii Chinenov Inez Rogatsky Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
description	Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this response in macrophage.
format	article
author	David A. Rollins Joubert B. Kharlyngdoh Maddalena Coppo Bowranigan Tharmalingam Sanda Mimouna Ziyi Guo Maria A. Sacta Miles A. Pufall Robert P. Fisher Xiaoyu Hu Yurii Chinenov Inez Rogatsky
author_facet	David A. Rollins Joubert B. Kharlyngdoh Maddalena Coppo Bowranigan Tharmalingam Sanda Mimouna Ziyi Guo Maria A. Sacta Miles A. Pufall Robert P. Fisher Xiaoyu Hu Yurii Chinenov Inez Rogatsky
author_sort	David A. Rollins
title	Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
title_short	Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
title_full	Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
title_fullStr	Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
title_full_unstemmed	Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
title_sort	glucocorticoid-induced phosphorylation by cdk9 modulates the coactivator functions of transcriptional cofactor grip1 in macrophages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eb8bc334966c4fed854765322ec786b6
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Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages

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