Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export

ABSTRACT Swarming colonies of the bacterium Proteus mirabilis are capable of self-recognition and territorial behavior. Swarms of independent P. mirabilis isolates can recognize each other as foreign and establish a visible boundary where they meet; in contrast, genetically identical swarms merge. T...

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Autores principales:	Larissa M. Wenren, Nora L. Sullivan, Lia Cardarelli, Alecia N. Septer, Karine A. Gibbs
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/eb8fd9c096c748fcbe0e9f6d54f9c33b
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spelling	oai:doaj.org-article:eb8fd9c096c748fcbe0e9f6d54f9c33b2021-11-15T15:43:09ZTwo Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export10.1128/mBio.00374-132150-7511https://doaj.org/article/eb8fd9c096c748fcbe0e9f6d54f9c33b2013-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00374-13https://doaj.org/toc/2150-7511ABSTRACT Swarming colonies of the bacterium Proteus mirabilis are capable of self-recognition and territorial behavior. Swarms of independent P. mirabilis isolates can recognize each other as foreign and establish a visible boundary where they meet; in contrast, genetically identical swarms merge. The ids genes, which encode self-identity proteins, are necessary but not sufficient for this territorial behavior. Here we have identified two new gene clusters: one (idr) encodes rhs-related products, and another (tss) encodes a putative type VI secretion (T6S) apparatus. The Ids and Idr proteins function independently of each other in extracellular transport and in territorial behaviors; however, these self-recognition systems are linked via this type VI secretion system. The T6S system is required for export of select Ids and Idr proteins. Our results provide a mechanistic and physiological basis for the fundamental behaviors of self-recognition and territoriality in a bacterial model system. IMPORTANCE Our results support a model in which self-recognition in P. mirabilis is achieved by the combined action of two independent pathways linked by a shared machinery for export of encoded self-recognition elements. These proteins together form a mechanistic network for self-recognition that can serve as a foundation for examining the prevalent biological phenomena of territorial behaviors and self-recognition in a simple, bacterial model system.Larissa M. WenrenNora L. SullivanLia CardarelliAlecia N. SepterKarine A. GibbsAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 4 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Larissa M. Wenren Nora L. Sullivan Lia Cardarelli Alecia N. Septer Karine A. Gibbs Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export
description	ABSTRACT Swarming colonies of the bacterium Proteus mirabilis are capable of self-recognition and territorial behavior. Swarms of independent P. mirabilis isolates can recognize each other as foreign and establish a visible boundary where they meet; in contrast, genetically identical swarms merge. The ids genes, which encode self-identity proteins, are necessary but not sufficient for this territorial behavior. Here we have identified two new gene clusters: one (idr) encodes rhs-related products, and another (tss) encodes a putative type VI secretion (T6S) apparatus. The Ids and Idr proteins function independently of each other in extracellular transport and in territorial behaviors; however, these self-recognition systems are linked via this type VI secretion system. The T6S system is required for export of select Ids and Idr proteins. Our results provide a mechanistic and physiological basis for the fundamental behaviors of self-recognition and territoriality in a bacterial model system. IMPORTANCE Our results support a model in which self-recognition in P. mirabilis is achieved by the combined action of two independent pathways linked by a shared machinery for export of encoded self-recognition elements. These proteins together form a mechanistic network for self-recognition that can serve as a foundation for examining the prevalent biological phenomena of territorial behaviors and self-recognition in a simple, bacterial model system.
format	article
author	Larissa M. Wenren Nora L. Sullivan Lia Cardarelli Alecia N. Septer Karine A. Gibbs
author_facet	Larissa M. Wenren Nora L. Sullivan Lia Cardarelli Alecia N. Septer Karine A. Gibbs
author_sort	Larissa M. Wenren
title	Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export
title_short	Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export
title_full	Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export
title_fullStr	Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export
title_full_unstemmed	Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export
title_sort	two independent pathways for self-recognition in <named-content content-type="genus-species">proteus mirabilis</named-content> are linked by type vi-dependent export
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/eb8fd9c096c748fcbe0e9f6d54f9c33b
work_keys_str_mv	AT larissamwenren twoindependentpathwaysforselfrecognitioninnamedcontentcontenttypegenusspeciesproteusmirabilisnamedcontentarelinkedbytypevidependentexport AT noralsullivan twoindependentpathwaysforselfrecognitioninnamedcontentcontenttypegenusspeciesproteusmirabilisnamedcontentarelinkedbytypevidependentexport AT liacardarelli twoindependentpathwaysforselfrecognitioninnamedcontentcontenttypegenusspeciesproteusmirabilisnamedcontentarelinkedbytypevidependentexport AT aleciansepter twoindependentpathwaysforselfrecognitioninnamedcontentcontenttypegenusspeciesproteusmirabilisnamedcontentarelinkedbytypevidependentexport AT karineagibbs twoindependentpathwaysforselfrecognitioninnamedcontentcontenttypegenusspeciesproteusmirabilisnamedcontentarelinkedbytypevidependentexport
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Two Independent Pathways for Self-Recognition in <named-content content-type="genus-species">Proteus mirabilis</named-content> Are Linked by Type VI-Dependent Export

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