COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS

Objective: To compare the efficacy of intralesional purified protein derivative (PPD) with conventional cryotherapy in the treatment of cutaneous warts. Study Design: Quasi experimental study. Place and Duration of Study: Dermatology Department, Pak Emirates Military Hospital (PEMH) Rawalpindi...

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Autores principales:	Syeda Midhat Fatima, Amer Ejaz, Ayesha Anwar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	cutaneous warts cryotherapy intralesional treatment Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eb910773df544cdf94deac17e24ad26a
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spelling	oai:doaj.org-article:eb910773df544cdf94deac17e24ad26a2021-11-09T02:46:01ZCOMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS0030-96482411-8842https://doaj.org/article/eb910773df544cdf94deac17e24ad26a2019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3396/2371https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare the efficacy of intralesional purified protein derivative (PPD) with conventional cryotherapy in the treatment of cutaneous warts. Study Design: Quasi experimental study. Place and Duration of Study: Dermatology Department, Pak Emirates Military Hospital (PEMH) Rawalpindi, from Jul 2017 to Jan 2018. Methodology: Total number of 60 patients were included in the study through Out Patient Department OPD. All patients were randomly divided in 2 groups by lottery method. Group A patients were given intra-lesional PPD (0.1ml in a single wart or targeting the largest wart in case of multiple warts, procedure was repeated fortnightly) while Group B patients were given cryotherapy with liquid nitrogen (2 freeze thaw cycles 20 sec duration each fortnightly). All patients were followed up after the end of treatment (maximum 6 sessions i.e. 3 months or complete clearance of wart whichever is earlier) and assessment of treatment efficacy was based on the response which was noted after 3 months of treatment. The response was categorized as excellent (no visible lesion), good (50-99% improvement), intermediate (<50% improvement) and poor (no response) depending upon the decrease in lesion numbers and size as measured by calibrated scale. The treatment was considered efficacious if there was good to excellent response. Results: A total of 21 (70%) cases in PPD and 9 (30%) cases in cryotherapy were treated successfully. Efficacy of treatment was significantly higher in PPD group compared to cryotherapy group, p-value <0.05. Conclusion: Intralesional purified protein derivative (PPD) was more effective in the treatment of cutaneous warts as compared to conventional cryotherapy. PPD may be adopted for treatment of viral warts to gain more satisfactory results and efficacy.Syeda Midhat FatimaAmer EjazAyesha AnwarArmy Medical College Rawalpindiarticlecutaneous wartscryotherapyintralesional treatmentMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 965-970 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cutaneous warts cryotherapy intralesional treatment Medicine R Medicine (General) R5-920
spellingShingle	cutaneous warts cryotherapy intralesional treatment Medicine R Medicine (General) R5-920 Syeda Midhat Fatima Amer Ejaz Ayesha Anwar COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS
description	Objective: To compare the efficacy of intralesional purified protein derivative (PPD) with conventional cryotherapy in the treatment of cutaneous warts. Study Design: Quasi experimental study. Place and Duration of Study: Dermatology Department, Pak Emirates Military Hospital (PEMH) Rawalpindi, from Jul 2017 to Jan 2018. Methodology: Total number of 60 patients were included in the study through Out Patient Department OPD. All patients were randomly divided in 2 groups by lottery method. Group A patients were given intra-lesional PPD (0.1ml in a single wart or targeting the largest wart in case of multiple warts, procedure was repeated fortnightly) while Group B patients were given cryotherapy with liquid nitrogen (2 freeze thaw cycles 20 sec duration each fortnightly). All patients were followed up after the end of treatment (maximum 6 sessions i.e. 3 months or complete clearance of wart whichever is earlier) and assessment of treatment efficacy was based on the response which was noted after 3 months of treatment. The response was categorized as excellent (no visible lesion), good (50-99% improvement), intermediate (<50% improvement) and poor (no response) depending upon the decrease in lesion numbers and size as measured by calibrated scale. The treatment was considered efficacious if there was good to excellent response. Results: A total of 21 (70%) cases in PPD and 9 (30%) cases in cryotherapy were treated successfully. Efficacy of treatment was significantly higher in PPD group compared to cryotherapy group, p-value <0.05. Conclusion: Intralesional purified protein derivative (PPD) was more effective in the treatment of cutaneous warts as compared to conventional cryotherapy. PPD may be adopted for treatment of viral warts to gain more satisfactory results and efficacy.
format	article
author	Syeda Midhat Fatima Amer Ejaz Ayesha Anwar
author_facet	Syeda Midhat Fatima Amer Ejaz Ayesha Anwar
author_sort	Syeda Midhat Fatima
title	COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS
title_short	COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS
title_full	COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS
title_fullStr	COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS
title_full_unstemmed	COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS
title_sort	comparison of efficacy of intralesional purified protein derivative (ppd) with cryotherapy in the treatment of cutaneous warts
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/eb910773df544cdf94deac17e24ad26a
work_keys_str_mv	AT syedamidhatfatima comparisonofefficacyofintralesionalpurifiedproteinderivativeppdwithcryotherapyinthetreatmentofcutaneouswarts AT amerejaz comparisonofefficacyofintralesionalpurifiedproteinderivativeppdwithcryotherapyinthetreatmentofcutaneouswarts AT ayeshaanwar comparisonofefficacyofintralesionalpurifiedproteinderivativeppdwithcryotherapyinthetreatmentofcutaneouswarts
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COMPARISON OF EFFICACY OF INTRALESIONAL PURIFIED PROTEIN DERIVATIVE (PPD) WITH CRYOTHERAPY IN THE TREATMENT OF CUTANEOUS WARTS

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