High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo

It is difficult to image haematopoietic stem cells (HSC) in their niche. Here, the authors present a new high-throughput computational approach to visualise HSCs in vivoat a high spatial and temporal resolution and also use a Msi2-reporter to label endogenous HSCs and progenitors, enabling cell trac...

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Autores principales: Claire S. Koechlein, Jeffrey R. Harris, Timothy K. Lee, Joi Weeks, Raymond G. Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P. Chute, Amit Chourasia, Markus W. Covert, Tannishtha Reya
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/eb98c9dbcd7d47d28ac28ab4c7bfb28b
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spelling oai:doaj.org-article:eb98c9dbcd7d47d28ac28ab4c7bfb28b2021-12-02T17:31:20ZHigh-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo10.1038/ncomms121692041-1723https://doaj.org/article/eb98c9dbcd7d47d28ac28ab4c7bfb28b2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12169https://doaj.org/toc/2041-1723It is difficult to image haematopoietic stem cells (HSC) in their niche. Here, the authors present a new high-throughput computational approach to visualise HSCs in vivoat a high spatial and temporal resolution and also use a Msi2-reporter to label endogenous HSCs and progenitors, enabling cell trackingClaire S. KoechleinJeffrey R. HarrisTimothy K. LeeJoi WeeksRaymond G. FoxBryan ZimdahlTakahiro ItoAllen BlevinsSeung-Hye JungJohn P. ChuteAmit ChourasiaMarkus W. CovertTannishtha ReyaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Claire S. Koechlein
Jeffrey R. Harris
Timothy K. Lee
Joi Weeks
Raymond G. Fox
Bryan Zimdahl
Takahiro Ito
Allen Blevins
Seung-Hye Jung
John P. Chute
Amit Chourasia
Markus W. Covert
Tannishtha Reya
High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
description It is difficult to image haematopoietic stem cells (HSC) in their niche. Here, the authors present a new high-throughput computational approach to visualise HSCs in vivoat a high spatial and temporal resolution and also use a Msi2-reporter to label endogenous HSCs and progenitors, enabling cell tracking
format article
author Claire S. Koechlein
Jeffrey R. Harris
Timothy K. Lee
Joi Weeks
Raymond G. Fox
Bryan Zimdahl
Takahiro Ito
Allen Blevins
Seung-Hye Jung
John P. Chute
Amit Chourasia
Markus W. Covert
Tannishtha Reya
author_facet Claire S. Koechlein
Jeffrey R. Harris
Timothy K. Lee
Joi Weeks
Raymond G. Fox
Bryan Zimdahl
Takahiro Ito
Allen Blevins
Seung-Hye Jung
John P. Chute
Amit Chourasia
Markus W. Covert
Tannishtha Reya
author_sort Claire S. Koechlein
title High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
title_short High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
title_full High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
title_fullStr High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
title_full_unstemmed High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
title_sort high-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/eb98c9dbcd7d47d28ac28ab4c7bfb28b
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AT jeffreyrharris highresolutionimagingandcomputationalanalysisofhaematopoieticcelldynamicsinvivo
AT timothyklee highresolutionimagingandcomputationalanalysisofhaematopoieticcelldynamicsinvivo
AT joiweeks highresolutionimagingandcomputationalanalysisofhaematopoieticcelldynamicsinvivo
AT raymondgfox highresolutionimagingandcomputationalanalysisofhaematopoieticcelldynamicsinvivo
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AT markuswcovert highresolutionimagingandcomputationalanalysisofhaematopoieticcelldynamicsinvivo
AT tannishthareya highresolutionimagingandcomputationalanalysisofhaematopoieticcelldynamicsinvivo
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