Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice

The aim of this study is to examine analgesic effect of Coenzyme Q10 ointment in mice. Fifteen healthy male albino mice were selected for this study. The animals were divided into three groups of five animals for each group. The pain reaction time was recorded pretreatment for each animal and was ta...

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Autores principales:	Ibtisam T. Al-Jureisy, Wael T. Al-Wattar, Ghada A. Taqa
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	coenzyme q10 ointment pain hot-plate test analgesia in mice maximal possible effect Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2019.20868.1001 https://doaj.org/article/eb99f8a477ff4136b6555825d3f84046
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spelling	oai:doaj.org-article:eb99f8a477ff4136b6555825d3f840462021-12-02T13:21:54ZEvaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Micehttps://dx.doi.org/10.21608/javs.2019.20868.10011687-40722090-3308https://doaj.org/article/eb99f8a477ff4136b6555825d3f840462020-01-01T00:00:00Zhttps://javs.journals.ekb.eg/article_67897.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308The aim of this study is to examine analgesic effect of Coenzyme Q10 ointment in mice. Fifteen healthy male albino mice were selected for this study. The animals were divided into three groups of five animals for each group. The pain reaction time was recorded pretreatment for each animal and was taken as a basal threshold(1). Group 1 served as a control and was applied Vaseline ointment topically on fore and hind limb. Group 2 and 3 were applied topically Coenzyme Q10 ointment 4%, 8% respectively on fore and hind limb. The onset and duration of analgesic effect of Coenzyme Q10 ointment were evaluated in mice by utilizing a Hot-Plate test at 55±1˚C. Latency reaction time was recorded after 3min. and (10- 60 min) after ointment applied. The prolongation of latency times compared with the values of the control was used to express about analgesic effects of Coenzyme Q10 ointment and the percentage of antinociceptive ,Maximal Possible Effect (MPE) was calculated. The Coenzyme Q10 ointment at concentrations (4%, 8%) produced analgesic effect in mice after 3 min, respectively in comparison with control. The percentage of maximum possible effect (MPE) was significantly increased in group treated with (4%,8%) Coenzyme Q10. It can be concluded that, the Coenzyme Q10 ointment have a good analgesic activity in mice after 3 minutes of topical application and prolong the duration of analgesia more than 40 minutes depending on concentration of Coenzyme Q10 ointment.Ibtisam T. Al-JureisyWael T. Al-WattarGhada A. TaqaEgyptian Society for Animal Managementarticlecoenzyme q10 ointmentpainhot-plate testanalgesia in micemaximal possible effectZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 1, Pp 11-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	coenzyme q10 ointment pain hot-plate test analgesia in mice maximal possible effect Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	coenzyme q10 ointment pain hot-plate test analgesia in mice maximal possible effect Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Ibtisam T. Al-Jureisy Wael T. Al-Wattar Ghada A. Taqa Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
description	The aim of this study is to examine analgesic effect of Coenzyme Q10 ointment in mice. Fifteen healthy male albino mice were selected for this study. The animals were divided into three groups of five animals for each group. The pain reaction time was recorded pretreatment for each animal and was taken as a basal threshold(1). Group 1 served as a control and was applied Vaseline ointment topically on fore and hind limb. Group 2 and 3 were applied topically Coenzyme Q10 ointment 4%, 8% respectively on fore and hind limb. The onset and duration of analgesic effect of Coenzyme Q10 ointment were evaluated in mice by utilizing a Hot-Plate test at 55±1˚C. Latency reaction time was recorded after 3min. and (10- 60 min) after ointment applied. The prolongation of latency times compared with the values of the control was used to express about analgesic effects of Coenzyme Q10 ointment and the percentage of antinociceptive ,Maximal Possible Effect (MPE) was calculated. The Coenzyme Q10 ointment at concentrations (4%, 8%) produced analgesic effect in mice after 3 min, respectively in comparison with control. The percentage of maximum possible effect (MPE) was significantly increased in group treated with (4%,8%) Coenzyme Q10. It can be concluded that, the Coenzyme Q10 ointment have a good analgesic activity in mice after 3 minutes of topical application and prolong the duration of analgesia more than 40 minutes depending on concentration of Coenzyme Q10 ointment.
format	article
author	Ibtisam T. Al-Jureisy Wael T. Al-Wattar Ghada A. Taqa
author_facet	Ibtisam T. Al-Jureisy Wael T. Al-Wattar Ghada A. Taqa
author_sort	Ibtisam T. Al-Jureisy
title	Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
title_short	Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
title_full	Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
title_fullStr	Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
title_full_unstemmed	Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
title_sort	evaluation of the analgesic activity of coenzyme q10 ointment in mice
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2019.20868.1001 https://doaj.org/article/eb99f8a477ff4136b6555825d3f84046
work_keys_str_mv	AT ibtisamtaljureisy evaluationoftheanalgesicactivityofcoenzymeq10ointmentinmice AT waeltalwattar evaluationoftheanalgesicactivityofcoenzymeq10ointmentinmice AT ghadaataqa evaluationoftheanalgesicactivityofcoenzymeq10ointmentinmice
_version_	1718393186615820288

Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice

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