The Escherichia coli transcriptome mostly consists of independently regulated modules

Mechanistic insight into the regulation of transcriptional modules remains scarce. Here, the authors identify statistically independent gene sets by applying independent component analysis to a high-quality E. coli RNA-seq data compendium and find that most gene sets represent the effects of specifi...

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Autores principales:	Anand V. Sastry, Ye Gao, Richard Szubin, Ying Hefner, Sibei Xu, Donghyuk Kim, Kumari Sonal Choudhary, Laurence Yang, Zachary A. King, Bernhard O. Palsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb9ab78b4746476baa464223205da6a1
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spelling	oai:doaj.org-article:eb9ab78b4746476baa464223205da6a12021-12-02T16:58:24ZThe Escherichia coli transcriptome mostly consists of independently regulated modules10.1038/s41467-019-13483-w2041-1723https://doaj.org/article/eb9ab78b4746476baa464223205da6a12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13483-whttps://doaj.org/toc/2041-1723Mechanistic insight into the regulation of transcriptional modules remains scarce. Here, the authors identify statistically independent gene sets by applying independent component analysis to a high-quality E. coli RNA-seq data compendium and find that most gene sets represent the effects of specific transcriptional regulators.Anand V. SastryYe GaoRichard SzubinYing HefnerSibei XuDonghyuk KimKumari Sonal ChoudharyLaurence YangZachary A. KingBernhard O. PalssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anand V. Sastry Ye Gao Richard Szubin Ying Hefner Sibei Xu Donghyuk Kim Kumari Sonal Choudhary Laurence Yang Zachary A. King Bernhard O. Palsson The Escherichia coli transcriptome mostly consists of independently regulated modules
description	Mechanistic insight into the regulation of transcriptional modules remains scarce. Here, the authors identify statistically independent gene sets by applying independent component analysis to a high-quality E. coli RNA-seq data compendium and find that most gene sets represent the effects of specific transcriptional regulators.
format	article
author	Anand V. Sastry Ye Gao Richard Szubin Ying Hefner Sibei Xu Donghyuk Kim Kumari Sonal Choudhary Laurence Yang Zachary A. King Bernhard O. Palsson
author_facet	Anand V. Sastry Ye Gao Richard Szubin Ying Hefner Sibei Xu Donghyuk Kim Kumari Sonal Choudhary Laurence Yang Zachary A. King Bernhard O. Palsson
author_sort	Anand V. Sastry
title	The Escherichia coli transcriptome mostly consists of independently regulated modules
title_short	The Escherichia coli transcriptome mostly consists of independently regulated modules
title_full	The Escherichia coli transcriptome mostly consists of independently regulated modules
title_fullStr	The Escherichia coli transcriptome mostly consists of independently regulated modules
title_full_unstemmed	The Escherichia coli transcriptome mostly consists of independently regulated modules
title_sort	escherichia coli transcriptome mostly consists of independently regulated modules
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eb9ab78b4746476baa464223205da6a1
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The Escherichia coli transcriptome mostly consists of independently regulated modules

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