Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study

Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondar...

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Autores principales:	Laura Martin-Piedra, Juan F. Alcala-Diaz, Francisco M. Gutierrez-Mariscal, Antonio P. Arenas de Larriva, Juan L. Romero-Cabrera, Jose D. Torres-Peña, Javier Caballero-Villarraso, Raul M. Luque, Pablo Perez-Martinez, Jose Lopez-Miranda, Javier Delgado-Lista
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obesity metabolic phenotypes metabolically healthy obese metabolically unhealthy obese fatty liver index diet intervention Mediterranean diet Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/eb9b4dd12b8b4ed98f22ff342f05eb21
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spelling	oai:doaj.org-article:eb9b4dd12b8b4ed98f22ff342f05eb212021-11-25T18:36:20ZEvolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study10.3390/nu131140462072-6643https://doaj.org/article/eb9b4dd12b8b4ed98f22ff342f05eb212021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4046https://doaj.org/toc/2072-6643Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (<i>p</i> < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes.Laura Martin-PiedraJuan F. Alcala-DiazFrancisco M. Gutierrez-MariscalAntonio P. Arenas de LarrivaJuan L. Romero-CabreraJose D. Torres-PeñaJavier Caballero-VillarrasoRaul M. LuquePablo Perez-MartinezJose Lopez-MirandaJavier Delgado-ListaMDPI AGarticleobesity metabolic phenotypesmetabolically healthy obesemetabolically unhealthy obesefatty liver indexdiet interventionMediterranean dietNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4046, p 4046 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity metabolic phenotypes metabolically healthy obese metabolically unhealthy obese fatty liver index diet intervention Mediterranean diet Nutrition. Foods and food supply TX341-641
spellingShingle	obesity metabolic phenotypes metabolically healthy obese metabolically unhealthy obese fatty liver index diet intervention Mediterranean diet Nutrition. Foods and food supply TX341-641 Laura Martin-Piedra Juan F. Alcala-Diaz Francisco M. Gutierrez-Mariscal Antonio P. Arenas de Larriva Juan L. Romero-Cabrera Jose D. Torres-Peña Javier Caballero-Villarraso Raul M. Luque Pablo Perez-Martinez Jose Lopez-Miranda Javier Delgado-Lista Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
description	Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (<i>p</i> < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes.
format	article
author	Laura Martin-Piedra Juan F. Alcala-Diaz Francisco M. Gutierrez-Mariscal Antonio P. Arenas de Larriva Juan L. Romero-Cabrera Jose D. Torres-Peña Javier Caballero-Villarraso Raul M. Luque Pablo Perez-Martinez Jose Lopez-Miranda Javier Delgado-Lista
author_facet	Laura Martin-Piedra Juan F. Alcala-Diaz Francisco M. Gutierrez-Mariscal Antonio P. Arenas de Larriva Juan L. Romero-Cabrera Jose D. Torres-Peña Javier Caballero-Villarraso Raul M. Luque Pablo Perez-Martinez Jose Lopez-Miranda Javier Delgado-Lista
author_sort	Laura Martin-Piedra
title	Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
title_short	Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
title_full	Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
title_fullStr	Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
title_full_unstemmed	Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
title_sort	evolution of metabolic phenotypes of obesity in coronary patients after 5 years of dietary intervention: from the cordioprev study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/eb9b4dd12b8b4ed98f22ff342f05eb21
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Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study

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